Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications [PDF]
International Journal of Molecular Sciences, 2023 Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in various biological tissues, including the kidney, lung, and colon. They enable the selective reabsorption of sodium ions, which is a process critical for controlling blood pressure, electrolyte balance, and overall fluid volume. ENaC activity is finely controlled
Mohammed Aufy, , Tamara Stojanović
exaly +8 more sources
Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC [PDF]
Molecular Brain, 2019 This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero +7 more
doaj +8 more sources
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit [PDF]
Journal of Biological Chemistry, 2022 The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α-ENaC and γ-ENaC; however, the proteases involved in the ...
Florian Sure +2 more
exaly +5 more sources
Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC)Research in context [PDF]
EBioMedicine, 2019 Background: Autosomal Recessive Polycystic Kidney Disease (ARPKD) is marked by cyst formation in the renal tubules, primarily in the collecting duct (CD) system, ultimately leading to end-stage renal disease.
Daria V. Ilatovskaya +8 more
doaj +4 more sources
Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation [PDF]
Experimental and Molecular Medicine, 2019 Blood pressure: Estrogen maintains the balance Estrogen treatment could prove valuable in tackling high blood pressure (hypertension) in postmenopausal women. Long-term healthy blood pressure is linked to the correct regulation of sodium and water levels
Xue Zhang +8 more
doaj +3 more sources
Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis [PDF]
Journal of Biological Chemistry, 2021 Mice lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity in the distal nephron and develop salt-sensitive hypertension. This indicates a functional link between Cx30 and ENaC, which remains incompletely understood. Here,
Alexandr V Ilyaskin +2 more
exaly +3 more sources
Antifibrotic Drugs Regulate the Expression of Epithelial Sodium Channels in the Lungs [PDF]
Advances in Respiratory MedicinePurpose: A high-salt extracellular environment promotes fibrosis in multiple organs by inducing oxidative stress, fibroblast activation, and extracellular matrix remodeling.
Toshiyuki Ito +13 more
doaj +2 more sources
Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction. [PDF]
Acta Physiol (Oxf)ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Essigke D +8 more
europepmc +2 more sources
Low-Salt Diet Induces Claudin-3 Expression and Drives Adaptive Changes in Collecting Duct of Claudin-3-Deficient Mice. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Renal sodium reabsorption occurs through both transcellular and paracellular pathways. Tight junction proteins play a key role in mediating paracellular transport. The collecting duct is critical for the fine tuning of sodium balance and is highly responsive to changes in dietary salt intake.
Sassi A +8 more
europepmc +2 more sources
Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor [PDF]
EMBO Molecular Medicine, 2018 The shift of cytokine profile from anti‐ to pro‐inflammatory is the most recognizable sign of labor, although the underlying mechanism remains elusive. Here, we report that the epithelial sodium channel (ENaC) is upregulated and activated in the uterus ...
Xiao Sun +15 more
doaj +2 more sources