Results 41 to 50 of about 10,384 (209)

Effect of kokumi taste-active γ-glutamyl peptides on amiloride-sensitive epithelial Na+ channels in rat fungiform taste cells

Biochemistry and Biophysics Reports, 2023
Kokumi taste-active compounds enhance salty taste perception. In animal models, sodium (salt) detection is mediated by the amiloride-sensitive epithelial sodium channel, ENaC.
Albertino Bigiani, MeeRa Rhyu
doaj   +1 more source

Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel

Scientific Reports, 2021
Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz, Antonio G. Soares, Elena Mironova, Nina Boiko, Amanpreet Kaur, Crystal R. Archer, James D. Stockand, Jonathan M. Berman   +7 more
doaj   +1 more source

Proteolytic Activation of the Epithelial Sodium Channel in Nephrotic Syndrome by Proteasuria: Concept and Therapeutic Potential

Turkish Journal of Nephrology, 2020
The epithelial sodium channel (ENaC) is expressed in the aldosterone-sensitive distal nephron, and it determines the final urinary sodium concentration.
Ferruh Artunç
doaj   +1 more source

Effects of syntaxins 2, 3, and 4 on rat and human epithelial sodium channel (ENaC) in Xenopus laevis oocytes. [PDF]

Pflugers Arch, 2020
Syntaxins are SNARE proteins and may play a role in epithelial sodium channel (ENaC) trafficking. The aim of the present study was to investigate the effects of syntaxin 2 (STX2), syntaxin 3 (STX3), and syntaxin 4 (STX4) on rat (rENaC) and human ENaC ...
Rauh R, Frost F, Korbmacher C.
europepmc   +2 more sources

Proteases, cystic fibrosis and the epithelial sodium channel (ENaC) [PDF]

Cell and Tissue Research, 2012
Proteases perform a diverse array of biological functions. From simple peptide digestion for nutrient absorption to complex signaling cascades, proteases are found in organisms from prokaryotes to humans. In the human airway, proteases are associated with the regulation of the airway surface liquid layer, tissue remodeling, host defense and pathogenic ...
P H, Thibodeau, M B, Butterworth
openaire   +2 more sources

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC) [PDF]

Journal of Biological Chemistry, 2017
Christine A Klemens, Robert S Edinger, Michael B Butterworth   +2 more
exaly   +2 more sources

Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC. [PDF]

Protein Expr Purif, 2016
The epithelial sodium channel (ENaC) plays a critical role in maintaining Na(+) homeostasis in various tissues throughout the body. An understanding of the structure of the ENaC subunits has been developed from homology modeling based on the related acid sensing ion channel 1 (ASIC1) protein structure, as well as electrophysiological approaches ...
Reddy BG, Dai Q, McNicholas CM, Fuller CM, Kappes JC, DeLucas LJ.   +5 more
europepmc   +4 more sources

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases

Gene, 2016
The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water homeostasis.
Israel Hanukoglu, A. Hanukoglu
semanticscholar   +1 more source

Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5 [PDF]

, 2009
Bacterial lipopolysaccharides (LPS) are potent inducers of proinflammatory signaling pathways via the activation of nuclear factor-kappa B (NF-KB) and mitogenactivated protein kinase (MAPK), causing changes in the processes that control lung fluid ...
A. M. Woollhead, Házeli, M. J., Baines, DL, M. J. Hazell, Baines, D. L., Woollhead, AM, M. E. C. Dockrell, L. Gambling, Gambling, L, A. P. Albert, Dockrell, ME, D. L. Baines, Dockrell, M. E. C., Hazell, MJ, Albert, A. P., Gambling, L., Woollhead, A. M., Albert, AP   +17 more
core   +1 more source

Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes

Membranes, 2023
The epithelial sodium channel (ENaC) is a key regulator of sodium homeostasis that contributes to blood pressure control. ENaC open probability is adjusted by extracellular sodium ions, a mechanism referred to as sodium self-inhibition (SSI).
Rene Y. Lawong, Fabian May, Etang C. Etang, Philipp Vorrat, Jonas George, Julia Weder, Dagmar Kockler, Matthias Preller, Mike Althaus   +8 more
doaj   +1 more source