Results 61 to 70 of about 10,384 (209)

High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2. [PDF]

PLoS ONE, 2012
Besides the kidneys, the gastrointestinal tract is the principal organ responsible for sodium homeostasis. For sodium transport across the cell membranes the epithelial sodium channel (ENaC) is of pivotal relevance.
Daniel Lienhard, Meret Lauterburg, Geneviève Escher, Felix J Frey, Brigitte M Frey   +4 more
doaj   +1 more source

The optimization of electrochemical immunosensors to detect epithelial sodium channel as a biomarker of hypertension

ADMET and DMPK, 2023
The epithelial sodium channel (ENaC) is a transmembrane protein that regulates the balance of sodium salt levels in the body through its expression in various tissues. The increase in sodium salt in the body is related to the expression of ENaC, thereby
Tias Febriana Hanifa Lestari, Riyanto Setiyono, Nina Tristina, Yulia Sofiatin, Yeni Wahyuni Hartati   +4 more
doaj   +1 more source

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity

Cell Reports, 2017
The homeostatic control of presynaptic neurotransmitter release stabilizes information transfer at synaptic connections in the nervous system of organisms ranging from insect to human. Presynaptic homeostatic signaling centers upon the regulated membrane
Brian O. Orr, David Gorczyca, Meg A. Younger, Lily Y. Jan, Yuh-Nung Jan, Graeme W. Davis   +5 more
doaj   +1 more source

Iron Inhibits the Translation and Activity of the Renal Epithelial Sodium Channel

Biology, 2022
Hypertension is associated with an increased renal expression and activity of the epithelial sodium channel (ENaC) and iron deficiency. Distal tubules absorb iron, causing perturbations that may influence local responses.
Abdel A. Alli, Ling Yu, Ewa Wlazlo, Sadat Kasem, Mohammed F. Gholam, Dhruv Desai, Carlos I. Lugo, Sophie Vaulont, Yogesh M. Scindia   +8 more
doaj   +1 more source

CRISPR/Cas9-Mediated α-ENaC Knockout in a Murine Pancreatic β-Cell Line

Frontiers in Genetics, 2021
Many ion channels participate in controlling insulin synthesis and secretion of pancreatic β-cells. Epithelial sodium channel (ENaC) expressed in human pancreatic tissue, but the biological role of ENaC in pancreatic β-cells is still unclear.
Xue Zhang, Lihua Zhao, Runbing Jin, Min Li, Mei-Shuang Li, Rongfeng Li, Xiubin Liang, Xiubin Liang   +7 more
doaj   +1 more source

Article Commentary: The Alternatively Spliced Form “b” of the Epithelial Sodium Channel α subunit (α ENaC): Any Prior Evidence of its Existence?

Clinical Medicine Insights: Cardiology, 2010
The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj   +1 more source

Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs) are members of a steroid hormone receptor superfamily that responds to changes in lipid and glucose homeostasis.
Tengis S. Pavlov, John D. Imig, Alexander Staruschenko   +2 more
doaj   +1 more source

Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production

Frontiers in Cell and Developmental Biology, 2022
The regulatory interaction between two typical epithelial ion channels, cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC), for epithelial homeostasis has been noted, although the underlying mechanisms ...
Fulei Wuchu, Xiyang Ma, Yanting Que, Junjiang Chen, Junjiang Chen, Ye Chun Ruan, Ye Chun Ruan   +6 more
doaj   +1 more source

Structure of the human epithelial sodium channel by cryo-electron microscopy

eLife, 2018
The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na+ and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel.
Sigrid Noreng, Arpita Bharadwaj, Richard Posert, Craig Yoshioka, Isabelle Baconguis   +4 more
doaj   +1 more source

Epithelial Sodium and Chloride Channels and Asthma

Chinese Medical Journal, 2015
Objective: To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel. Data Sources: The data analyzed in this review were the English articles from 1980 to 2015 from journal ...
Wen Wang, Hong-Long Ji
doaj   +1 more source