Results 81 to 90 of about 10,384 (209)

Molecular modeling of mechanosensory ion channel structural and functional features.

PLoS ONE, 2010
The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of ...
Renate Gessmann, Nikos Kourtis, Kyriacos Petratos, Nektarios Tavernarakis   +3 more
doaj   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

The epithelial sodium channel and the processes of wound healing [PDF]

, 2019
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways.
Chifflet, Silvia, Hernández Garrido, Julio Andrés   +1 more
core   +2 more sources

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth.

, 2013
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett, Tarran Robert, Ward, Christopher, Ward Christopher, Michael A Gray, Baines, DL, Garnett, James P., Robert Tarran, Christopher Ward, Ward, C, Garnett, JP, Baker, EH, Brodlie Malcolm, Baker, Emma H., Tarran, Robert, Gray Michael A., Brodlie, Malcolm, Baker Emma H., Garnett James P., Brodlie, M, Deborah L Baines, Baines Deborah L., Gray, Michael A., Baines, Deborah L., Gray, MA, Malcolm Brodlie, Tarran, R, Emma H Baker   +27 more
core   +1 more source

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport

Life Science Alliance
The membrane-bound serine protease Tmprss2 is required for ENaC-mediated transepithelial sodium and EpCAM-mediated paracellular transport in kidney cells.
Olivia J Rickman, Emma Guignard, Thomas Chabanon, Giovanni Bertoldi, Muriel Auberson, Edith Hummler   +5 more
doaj   +1 more source

Mechanism of Fluid Reabsorption in Kidney Proximal Tubule: Interplay Between Lateral Na+/K+‐ATPase and AQP1 and SGLT1 Mediated Water Fluxes

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The mechanism of isosmotic water reabsorption in the kidney proximal tubule, with a focus on the interaction between the lateral Na+/K+‐ATPase, apical water pathways mediated by AQP1 and SGLT1, and paracellular water flow through Claudin‐2. Methods A mathematical model of proximal tubular transport was used to compute coupled ion, solute,
Erik Hviid Larsen, Jens Nørkær Sørensen   +1 more
wiley   +1 more source

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC)

, 2019
Research paper describing the interaction of the epithelial sodium channel (ENaC) and the scaffolding protein ankyrin G (AnkG) in renal collecting duct ...
Lindsay Kighlinger (6428990), Xiaoning Liu (588784), Robert S. Edinger (131846), Christine A Klemens (6428988), Michael B. Butterworth (131855)   +4 more
core   +1 more source