Results 71 to 80 of about 10,384 (209)

Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling

Molecules, 2022
THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC)
Maria Mernea, Roxana Ștefania Ulăreanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihăilescu   +7 more
doaj   +1 more source

Hormonal Regulation of the Epithelial Sodium Channel ENaC [PDF]

The Journal of General Physiology, 2002
Despite large changes in water and salt intake, the kidney is able to maintain the extracellular osmolarity and volume within narrow margins (Verrey et al., 2000). Such fine control requires specific factors or hormones; among them, aldosterone and antidiuretic hormone (ADH) (vasopressin in mammals) play the key role.
openaire   +2 more sources

Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Journal of Pharmacological Sciences, 2022
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic ...
Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto   +14 more
doaj   +1 more source

Role of epithelial sodium channels (ENaCs) in endothelial function [PDF]

Journal of Cell Science, 2015
An increasing number of mechano-sensitive ion channels in endothelial cells (ECs) have been identified in response to blood flow and hydrostatic pressure. However, how these channels response to flow under different physiological and pathological conditions remains unknown. Our results showed that ENaCs were co-localized with hemeoxygenase-1 (HO-1) and
Dongqing Guo, Shenghui Liang, Su Wang, Chengchun Tang, Bin Yao, Wenhui Wan, Hailing Zhang, Hui Jiang, Asif Ahmed, Zhiren Zhang, Yuchun Gu   +10 more
openaire   +1 more source

Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel

Frontiers in Physiology, 2022
The mechanistic target of rapamycin (mTOR), a serine-threonine-specific kinase, is a cellular energy sensor, integrating growth factor and nutrient signaling.
Bruce Chen, Maurice B. Fluitt, Maurice B. Fluitt, Aaron L. Brown, Samantha Scott, Anirudh Gadicherla, Carolyn M. Ecelbarger   +6 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Can trigeminal sensations impact saltiness perception? A mini‐review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan, Nicoletta Faraone, Matthew B McSweeney   +2 more
wiley   +1 more source

COMMD10 in epithelial sodium channel (ENaC) trafficking [PDF]

, 2020
The epithelial sodium channel (ENaC), is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ and is selectively permeable to Na+ ions.
Rasulov, Sahib
core   +1 more source

Detection of renal tubular transporter proteins in canine urinary extracellular vesicles using liquid chromatography–tandem mass spectrometry

Veterinary Clinical Pathology, EarlyView.
Abstract Urinary extracellular vesicles (UEVs) are membranous particles that carry renal tubular transporter proteins. Here, we evaluate whether selected renal tubular transporter proteins can be detected in UEVs isolated from small volume (1–5 mL) canine urine samples of healthy dogs and canine patients with elevated circulating parathyroid hormone ...
L. J. McGravey, P. R. Antrobus, T. L. Williams   +2 more
wiley   +1 more source

Peripheral localization of the epithelial sodium channel (ENaC) in the apical membrane of bronchial epithelial cells

, 2019
What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance?
Musante I, Guidone D, Castellani S., Venturini A, Galietta LJV., Scudieri P., Venturini A., Caci E., Scudieri P, Caci E, Conese M., Castellani S, Musante I., Guidone D., Galietta L. J. V., Conese M   +15 more
core   +1 more source