Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?
Frontiers in Cardiovascular Medicine, 2022 Hypertension is a risk factor for end organ damage and death and is more common in persons with HIV compared to the general population. Several mechanisms have been studied in the pathogenesis of hypertension.
Katongo H. Mutengo +6 more
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P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
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(Pro)Renin receptor mediates obesity-induced antinatriuresis and elevated blood pressure via upregulation of the renal epithelial sodium channel. [PDF]
PLoS ONE, 2018 Recent studies have demonstrated that the renal (pro)renin receptor (PRR) regulates expression of the alpha subunit of the epithelial sodium channel (α-ENaC).
Syed S Quadri +4 more
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Epithelial sodium channel (ENaC) and pregnancy
The FASEB Journal, 2009 A healthy pregnancy requires avid retention of sodium (Na) and plasma volume expansion (PVE) in order to provide adequate blood supply to the growing fetus. We performed in vivo and in vitro studies to
Crystal West +3 more
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Mechanosensitivity of the Epithelial Sodium Channel (ENaC): Controversy or Pseudocontroversy? [PDF]
The Journal of General Physiology, 1998 Amiloride-sensitive epithelial sodium channels constitute the rate-limiting step for sodium reabsorption in the distal part of the renal tubule, in the distal colon, in the ducts of several exocrine glands, and in the airways (Rossier et al., 1994).
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The role of the epithelial Na+ channel (ENaC) in high AVP but low aldosterone states
Frontiers in Physiology, 2012 Due to the abundance of seminal discoveries establishing a strong causal relation between changes in aldosterone signaling, the activity of the epithelial Na+ channel (ENaC) and blood pressure, the role of ENaC in health and disease is understood almost ...
James D Stockand
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PIP2 Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells
Biology, 2022 We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-bisphosphate (PIP2).
Qiang Yue +6 more
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ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases [PDF]
Journal of Biological Chemistry, 2009 Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia. Proteolytic cleavage has an important role in regulating the activity of these channels by increasing their open probability. Specific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at defined sites within their ...
Thomas R, Kleyman +2 more
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Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia
Hypertension in Pregnancy, 2023 Objective To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls.
P.Y.M. Leung +9 more
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PLoS ONE, 2015 The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC).
Anna Keppner +9 more
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