International Journal of Biological Sciences, 2007 The amiloride-sensitive epithelial sodium channel (ENaC), a plasma membrane protein mediates sodium reabsorption in epithelial tissues, including the distal nephron and colon.
Sunil K Saxena, Madhurima Singh, Simarna Kaur, Constantine George
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DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. [PDF]
Int J Mol Sci, 2021 The interplay between the cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC) in respiratory epithelia has a crucial role in the pathogenesis of cystic fibrosis (CF).
Pierandrei S +8 more
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mTORC2, a Novel " Twist " on the Epithelial Sodium Channel (ENaC). [PDF]
J Am Soc Nephrol, 2023 Ellison DH, Ellison DH, McCormick JA.
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Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting. [PDF]
Cell Mol Life Sci, 2022 The pathogenic mechanism of cystic fibrosis (CF) includes the functional interaction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein with the epithelial sodium channel (ENaC).
Blaconà G +8 more
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Epithelial sodium channel (ENaC) in GtoPdb v.2025.3
IUPHAR/BPS Guide to Pharmacology CITEOverviewThe epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [10, 49, 15, 24, 23].
Israel Hanukoglu
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Dexmedetomidine alleviates pulmonary edema through the epithelial sodium channel (ENaC) via the PI3K/Akt/Nedd4-2 pathway in LPS-induced acute lung injury. [PDF]
Immunol Res, 2021 Dexmedetomidine (Dex), a highly selective α2-adrenergic receptor (α2AR) agonist, has an anti-inflammatory property and can alleviate pulmonary edema in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the mechanism is still unclear.
Jiang Y +5 more
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Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner. [PDF]
J Gen Physiol, 2020 In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor
Mansley MK +7 more
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Clinical Endocrinology, 2005 Objectives Multisystem pseudohypoaldosteronism (PHA) is a rare autosomal recessive aldosterone unresponsiveness syndrome that results from mutations in the genes encoding epithelial sodium channel (ENaC) subunits alpha, beta and gamma.
Hanukoglu, I +7 more
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Automated patch-clamp recordings for detecting activators and inhibitors of the epithelial sodium channel (ENaC). [PDF]
Pflugers ArchThe epithelial sodium channel (ENaC) is crucial for sodium absorption in several epithelial tissues including lung and kidney. Its involvement in various renal and pulmonary disorders makes ENaC a potential drug target.
Sure F +7 more
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Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancy. [PDF]
PLoS ONE, 2013 The purpose of the study is to investigate the expression of epithelial sodium channel (ENaC) in normal pregnancy and severe preeclampsia placenta and to explore the underlying mechanism of the relationship between the altered ENaC expression and onset ...
Shan Wang +7 more
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