Results 11 to 20 of about 10,384 (209)

Regulation of the epithelial sodium channel (ENaC) by membrane trafficking

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
The epithelial Na(+) channel (ENaC) is a major regulator of salt and water reabsorption in a number of epithelial tissues. Abnormalities in ENaC function have been directly linked to several human disease states including Liddle syndrome, psuedohypoaldosteronism, and cystic fibrosis and may be implicated in salt-sensitive hypertension. ENaC activity in
Michael B. Butterworth, Butterworth, Michael B.   +1 more
core   +4 more sources

Zymogen‐locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice [PDF]

Acta Physiologica, 2021
The serine protease prostasin (Prss8) is expressed in the distal tubule and stimulates proteolytic activation of the epithelial sodium channel (ENaC) in co‐expression experiments in vitro.
Daniel Essigke, Alexandr V Ilyaskin, Matthias Worn   +2 more
exaly   +3 more sources

Epithelial sodium channel (ENaC) in GtoPdb v.2025.4

IUPHAR/BPS Guide to Pharmacology CITE
OverviewEpithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lungs, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and several other organs [10, 17, 26, 25, 57]. In these epithelia, Na+ ions enter epithelial cells from the extracellular fluid
Hanukoglu, Israel
core   +4 more sources

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis. [PDF]

Curr Opin Pharmacol, 2018
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and hyperviscous mucus, among other pathologies of host defense.
Shei RJ, Peabody JE, Kaza N, Rowe SM.
europepmc   +5 more sources

The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. [PDF]

PLoS ONE, 2012
The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na(+) transport ...
Robert S Edinger, Carol A Bertrand, Christine Rondandino, Gerard A Apodaca, John P Johnson, Michael B Butterworth   +5 more
doaj   +3 more sources

Clinical Application of Epithelial Sodium Channel (ENaC) as a Biomarker for Arterial Hypertension. [PDF]

Biosensors (Basel), 2022
Arterial hypertension (HTN) is a global public health concern and an important risk factor for cardiovascular diseases and renal failure. We previously reported overexpression of ENaC on the plasma membrane of human platelets is a hallmark of HTN. In this double-blinded study of an open population (n = 167), we evaluated the sensitivity and specificity
García-Rubio D, Martínez-Vieyra I, de la Mora MB, Fuentes-García MA, Cerecedo D.   +4 more
europepmc   +5 more sources

The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. [PDF]

Biochem J, 2016
The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either result in profound changes in blood pressure.
Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS.   +16 more
europepmc   +7 more sources

Epithelial sodium channel (ENaC) in GtoPdb v.2021.2

IUPHAR/BPS Guide to Pharmacology CITE, 2021
The epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [9, 13, 22, 21, 42].
Hanukoglu, Israel
openaire   +3 more sources

Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site [PDF]

Journal of Biological Chemistry, 2016
The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin ion channel family, which also includes the bile acid-sensitive ion channel (BASIC). So far little is known about the effects of bile acids on ENaC function.
Alexandr V Ilyaskin, Alexei Diakov, Christoph Korbmacher   +2 more
exaly   +3 more sources

Anionic Phospholipids Regulate Native and Expressed Epithelial Sodium Channel (ENaC) [PDF]

Journal of Biological Chemistry, 2002
Using patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity in the apical membrane of A6 distal nephron cells showed a sudden rundown beginning at 4 min after forming the inside-out configuration. This sudden rundown was prevented by addition of anionic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP(2 ...
He-Ping, Ma, Sunil, Saxena, David G, Warnock   +2 more
openaire   +3 more sources