Results 1 to 10 of about 22,476 (217)

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Toxins, 2023
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N Lyukmanova, Maxim M Zaigraev, Dmitrii S Kulbatskii   +2 more
exaly   +4 more sources

Expression profiles of SGK-1 and α-ENaC in minor salivary glands of subjects with xerostomia [PDF]

Frontiers in Dental Medicine
IntroductionEpithelial sodium channel (ENaC) is a major conduit for sodium transport across the cell membrane, and its activity is regulated by multiple factors/mechanisms, including the serum and glucocorticoid-regulated kinase-1 (SGK-1).
Mahmood S. Mozaffari, Rafik Abdelsayed
doaj   +2 more sources

Role of epithelial sodium channel-related inflammation in human diseases

Frontiers in Immunology, 2023
The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout the kidneys, blood vessels, lungs, colons, and many other organs.
Yabin Chen, Yabin Chen, Yabin Chen, Xiao Yu, Xiao Yu, Xiao Yu, Zhiping Yan, Zhiping Yan, Shuijun Zhang, Jiacheng Zhang, Wenzhi Guo, Wenzhi Guo   +11 more
doaj   +1 more source

A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome

Blood Pressure, 2021
Purpose Liddle syndrome is a hereditary form of arterial hypertension caused by mutations in the genes coding of the epithelial sodium channel – SCNN1A, SCNN1B and SCNN1G.
Štěpán Mareš, Jan Filipovský, Kateřina Vlková, Martin Pešta, Václava Černá, Jaroslav Hrabák, Jitka Mlíková Seidlerová, Otto Mayer   +7 more
doaj   +1 more source

CRISPR/Cas9-Mediated α-ENaC Knockout in a Murine Pancreatic β-Cell Line

Frontiers in Genetics, 2021
Many ion channels participate in controlling insulin synthesis and secretion of pancreatic β-cells. Epithelial sodium channel (ENaC) expressed in human pancreatic tissue, but the biological role of ENaC in pancreatic β-cells is still unclear.
Xue Zhang, Lihua Zhao, Runbing Jin, Min Li, Mei-Shuang Li, Rongfeng Li, Xiubin Liang, Xiubin Liang   +7 more
doaj   +1 more source

The optimization of electrochemical immunosensors to detect epithelial sodium channel as a biomarker of hypertension

ADMET and DMPK, 2023
The epithelial sodium channel (ENaC) is a transmembrane protein that regulates the balance of sodium salt levels in the body through its expression in various tissues. The increase in sodium salt in the body is related to the expression of ENaC, thereby
Tias Febriana Hanifa Lestari, Riyanto Setiyono, Nina Tristina, Yulia Sofiatin, Yeni Wahyuni Hartati   +4 more
doaj   +1 more source

Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity

Cells, 2023
The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo.
Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H. Bugge, Simona Frateschi, Edith Hummler   +9 more
doaj   +1 more source

Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption

Upsala Journal of Medical Sciences, 2020
Background The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport.
Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Anders Arner, Judith Hartleib-Geschwindner, Johan Sällström   +5 more
doaj   +1 more source

Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Angiotensin II stimulates epithelial Na+ channel (ENaC) by aldosterone‐independent mechanism. We now test the effect of angiotensin II on ENaC in the distal convoluted tubule (DCT) and cortical collecting duct (CCD) of wild‐type (WT) and ...
Peng Wu, Zhong‐Xiuzi Gao, Dan‐Dan Zhang, Xin‐Peng Duan, Andrew S. Terker, Dao‐Hong Lin, David H. Ellison, Wen‐Hui Wang   +7 more
doaj   +1 more source

Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes

Membranes, 2023
The epithelial sodium channel (ENaC) is a key regulator of sodium homeostasis that contributes to blood pressure control. ENaC open probability is adjusted by extracellular sodium ions, a mechanism referred to as sodium self-inhibition (SSI).
Rene Y. Lawong, Fabian May, Etang C. Etang, Philipp Vorrat, Jonas George, Julia Weder, Dagmar Kockler, Matthias Preller, Mike Althaus   +8 more
doaj   +1 more source