Results 21 to 30 of about 22,476 (217)

Intact cytoskeleton is required for small G protein dependent activation of the epithelial Na+ channel. [PDF]

PLoS ONE, 2010
BACKGROUND: The Epithelial Na(+) Channel (ENaC) plays a central role in control of epithelial surface hydration and vascular volume. Similar to other ion channels, ENaC activity is regulated, in part, by cortical cytoskeleton.
Alexey V Karpushev, Daria V Ilatovskaya, Tengis S Pavlov, Yuri A Negulyaev, Alexander Staruschenko   +4 more
doaj   +1 more source

Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5 [PDF]

, 2009
Bacterial lipopolysaccharides (LPS) are potent inducers of proinflammatory signaling pathways via the activation of nuclear factor-kappa B (NF-KB) and mitogenactivated protein kinase (MAPK), causing changes in the processes that control lung fluid ...
A. M. Woollhead, Házeli, M. J., Baines, DL, M. J. Hazell, Baines, D. L., Woollhead, AM, M. E. C. Dockrell, L. Gambling, Gambling, L, A. P. Albert, Dockrell, ME, D. L. Baines, Dockrell, M. E. C., Hazell, MJ, Albert, A. P., Gambling, L., Woollhead, A. M., Albert, AP   +17 more
core   +1 more source

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Journal of Experimental Pharmacology, 2021
Madalena C Pinto,1,* Iris AL Silva,1,* Miriam F Figueira,2 Margarida D Amaral,1 Miquéias Lopes-Pacheco1,* 1Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Lisboa, Portugal; 2Marsico Lung ...
Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M   +4 more
doaj  

TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B

Frontiers in Immunology, 2017
Previous in vitro studies have indicated that tumor necrosis factor (TNF) activates amiloride-sensitive epithelial sodium channel (ENaC) current through its lectin-like (TIP) domain, since cyclic peptides mimicking the TIP domain (e.g., solnatide ...
Anita Willam, Anita Willam, Mohammed Aufy, Susan Tzotzos, Dina El-Malazi, Franziska Poser, Alina Wagner, Birgit Unterköfler, Didja Gurmani, David Martan, Shahid Muhammad Iqbal, Bernhard Fischer, Hendrik Fischer, Helmut Pietschmann, Istvan Czikora, Rudolf Lucas, Rosa Lemmens-Gruber, Waheed Shabbir, Waheed Shabbir   +18 more
doaj   +1 more source

The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. [PDF]

PLoS ONE, 2012
The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na(+) transport ...
Robert S Edinger, Carol A Bertrand, Christine Rondandino, Gerard A Apodaca, John P Johnson, Michael B Butterworth   +5 more
doaj   +1 more source

A voltammetric immunosensor based on gold nanoparticle - Anti-ENaC bioconjugate for the detection of epithelial sodium channel (ENaC) protein as a biomarker of hypertension

Sensing and Bio-Sensing Research, 2020
Epithelial sodium channel (ENaC) is a protein that has a central role in the development of hypertension. ENaC is a transmembrane protein that overexpressed in arterial hypertension patients.
Yeni Wahyuni Hartati, Shabarni Gaffar, Desmila Alfiani, Uji Pratomo, Yulia Sofiatin, Toto Subroto   +5 more
doaj   +1 more source

Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane

Frontiers in Physiology, 2019
The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell.
Tanya T. Cheung, Noor A. S. Ismail, Noor A. S. Ismail, Rachel Moir, Nikhil Arora, Fiona J. McDonald, Steven B. Condliffe   +6 more
doaj   +1 more source

Iron Inhibits the Translation and Activity of the Renal Epithelial Sodium Channel

Biology, 2022
Hypertension is associated with an increased renal expression and activity of the epithelial sodium channel (ENaC) and iron deficiency. Distal tubules absorb iron, causing perturbations that may influence local responses.
Abdel A. Alli, Ling Yu, Ewa Wlazlo, Sadat Kasem, Mohammed F. Gholam, Dhruv Desai, Carlos I. Lugo, Sophie Vaulont, Yogesh M. Scindia   +8 more
doaj   +1 more source

Organization of the ENaC-regulatory machinery [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2012
The control of fluid and electrolyte homeostasis in vertebrates requires the integration of a diverse set of signaling inputs, which control epithelial Na(+) transport, the principal ionic component of extracellular fluid. The key site of regulation is a segment of the kidney tubules, frequently termed the aldosterone-sensitive distal nephron, wherein ...
Rama, Soundararajan, Ming, Lu, David, Pearce   +2 more
openaire   +2 more sources

Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia

Hypertension in Pregnancy, 2023
Objective To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls.
P.Y.M. Leung, M Katerelos, S. Choy, N Cook, M Lee, K Paizis, A Abboud, J. A. Manning, P.F Mount, D.A Power   +9 more
doaj   +1 more source