Results 21 to 30 of about 10,384 (209)

Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.

Kidney International, 2017
Volume retention in nephrotic syndrome has been linked to activation of the epithelial sodium channel (ENaC) by proteolysis of its γ-subunit following urinary excretion of serine proteases such as plasmin.
Bohnert, B.N., Daniel, C., Häring, H.-U., Bertog, M., Menacher, M., Schork, A., Daiminger, S., Kalbacher, H., Korbmacher, C., Haerteis, S., Janessa, A., Sure, F., Amann, K., Wörn, M., Artunc, F.   +14 more
core   +2 more sources

Epithelial sodium channel (ENaC) in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE, 2023
OverviewThe epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [10, 48, 14, 23, 22].
Israel Hanukoglu
openaire   +2 more sources

The δ-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation [PDF]

Journal of Biological Chemistry, 2009
The epithelial sodium channel (ENaC) is probably a heterotrimer with three well characterized subunits (alphabetagamma). In humans an additional delta-subunit (delta-hENaC) exists but little is known about its function. Using the Xenopus laevis oocyte expression system, we compared the functional properties of alphabetagamma- and deltabetagamma-hENaC ...
Silke, Haerteis, Bettina, Krueger, Christoph, Korbmacher, Robert, Rauh   +3 more
openaire   +3 more sources

The Alternatively Spliced Form “b” of the Epithelial Sodium Channel α Subunit (α ENaC): Any Prior Evidence of its Existence?

Clinical Medicine Insights: Cardiology, 2010
The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj   +1 more source

Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface [PDF]

Biochemical Journal, 2007
The human ENaC (epithelial sodium channel), a complex of three subunits, provides the rate-limiting step for sodium uptake in the distal nephron, and therefore plays a key role in salt homoeostasis and in regulating blood pressure. The number of active sodium channel complexes present at the plasma membrane appears to be tightly controlled. In Liddle's
Dominik, Wiemuth, Ying, Ke, Meino, Rohlfs, Fiona J, McDonald   +3 more
openaire   +3 more sources

Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)

American Journal of Physiology-Renal Physiology, 2012
Expression of the epithelial sodium channel (ENaC) at the apical membrane of cortical collecting duct (CCD) principal cells is modulated by regulated trafficking mediated by vesicle insertion and retrieval. Small GTPases are known to facilitate vesicle trafficking, recycling, and membrane fusion events; however, little is known ...
Michael B, Butterworth, Robert S, Edinger, Mark R, Silvis, Luciana I, Gallo, Xiubin, Liang, Gerard, Apodaca, Raymond A, Frizzell, Raymond A, Fizzell, John P, Johnson   +8 more
openaire   +4 more sources

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiologica, 2019
Aim In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC)
Bohnert, B.N., Sophie Daiminger, Wörn, Matthias, Daiminger, S., Haerteis, Silke, Artunc, Ferruh, Schneider, Jonas C., Batbouta, Firas, Staudner, T., Sure, Florian, Ferruh Artunc, Essigke, Daniel, Kanse, S., Haerteis, S., Christoph Korbmacher, Kanse, Sandip, Ilyaskin, A.V., Batbouta, F., Ilyaskin, Alexandr V., Wörn, M., Florian Sure, Tobias Staudner, Matthias Wörn, Jonas C. Schneider, Essigke, D., Silke Haerteis, Bohnert, Bernhard N., Korbmacher, C., Staudner, Tobias, Korbmacher, Christoph, Sure, F., Janessa, A., Bernhard N. Bohnert, Firas Batbouta, Janessa, Andrea, Daiminger, Sophie, Daniel Essigke, Sandip Kanse, Andrea Janessa, Artunc, F., Schneider, J.C., Alexandr V. Ilyaskin   +41 more
core   +2 more sources

Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC). [PDF]

Front Cell Dev Biol, 2021
Background Hyperhomocysteinemia (HHcy) causes cardiovascular diseases via regulating inflammatory responses. We investigated whether and how the epithelial sodium channel (ENaC), a recently identified ion channel in endothelial cells, plays a role in ...
Liang C, Wang QS, Yang X, Zhu D, Sun Y, Niu N, Yao J, Dong BH, Jiang S, Tang LL, Lou J, Yu CJ, Shao Q, Wu MM, Zhang ZR.   +14 more
europepmc   +2 more sources

Hydration Status Regulates Sodium Flux and Inflammatory Pathways through Epithelial Sodium Channel (ENaC) in the Skin

Journal of Investigative Dermatology, 2015
Although it is known that the inflammatory response that results from disruption of epithelial barrier function after injury results in excessive scarring, the upstream signals remain unknown.
Zhong, Aimei, Galiano, Robert D., Cooper, Garry, Qureshi, Hannan A., Porterfield, Marshall D., Mustoe, Thomas A., Hong, Seok Jong, Surmeier, D James, Xu, Wei, Zeitchek, Michael, Jia, Shengxian, Xie, Ping   +11 more
core   +2 more sources

Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice. [PDF]

Pflugers Arch, 2022
Proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases is thought to contribute to renal sodium retention in nephrotic syndrome. However, the identity of the responsible proteases remains elusive.
Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM.   +14 more
europepmc   +2 more sources