Results 101 to 110 of about 10,384 (209)
CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes
, 2005 The cystic fibrosis transmembrane conductance regulator (CFTR) plays a crucial role in regulating fluid secretion by the airways, intestines, sweat glands and other epithelial tissues.
Brochiero, E. +5 more
core +1 more source
Scientific Reports, 2017 The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function.
Maria D. I. Manunta +8 more
doaj +1 more source
The endothelial αENaC contributes to vascular endothelial function in vivo. [PDF]
PLoS ONE, 2017 The Epithelial Sodium Channel (ENaC) is a key player in renal sodium homeostasis. The expression of α β γ ENaC subunits has also been described in the endothelium and vascular smooth muscle, suggesting a role in vascular function.
Antoine Tarjus +9 more
doaj +1 more source
Aldosterone Modulates the Association between NCC and ENaC
Scientific Reports, 2017 Distal sodium transport is a final step in the regulation of blood pressure. As such, understanding how the two main sodium transport proteins, the thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC), are ...
Brandi M. Wynne +6 more
doaj +1 more source
Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg +8 more
wiley +1 more source
Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC) [PDF]
, 2011 All animals use a sophisticated array of receptor proteins to sense their external and internal environments. Major advances have been made in recent years in understanding the molecular and genetic bases for sensory transduction in diverse modalities, indicating that both metabotropic and ionotropic pathways are important in sensory functions. Here, I
openaire +2 more sources
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, Volume 16, Issue 4, Page 778-787, April 2026.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Communications BiologyThe epithelial sodium channel (ENaC) is essential for osmoregulation in tetrapod vertebrates. There are four ENaC-subunits (α, β, γ, δ) which form αβγ- or δβγ-ENaCs. While αβγ-ENaC is a ‘maintenance protein’ controlling sodium homeostasis, δβγ-ENaC might
Fynn Zahnow +14 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure.
Yu-Jia Zhai +11 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Nocardia infection should be considered in immunocompromised patients presenting with concurrent pulmonary and neurological symptoms. Species identification and antimicrobial susceptibility testing are crucial. Co‐trimoxazole is the first‐line treatment.
Varun Mamidi, Constantina Chrysochou
wiley +1 more source