Results 121 to 130 of about 10,384 (209)

Rab22 is involved in regulation of the epithelial sodium channel (ENaC)

The FASEB Journal, 2013
We previously demonstrated a role for small GTPases in the regulation of the epithelial sodium channel (ENaC) in epithelial cells of the distal kidney nephron. To further map the trafficking itinerary of ENaC in mouse cortical collecting duct (mCCD) cells, we investigated a number of other GTPases for their ability to alter ENaC function ...
Xiaoning Liu, Claudia Bertuccio, Daniel Devor, Michael Butterworth   +3 more
openaire   +1 more source

Epithelial sodium channel regulatory proteins identified by functional expression cloning

, 1998
Epithelial sodium channel regulatory proteins identified by functional expression cloning. We describe here our current strategy for identifying and cloning proteins involved in the regulation of the epithelial sodium channel (ENaC).
Rossier, Bernard C., Vallet, Véronique, Horisberger, Jean-Daniel   +2 more
core   +1 more source

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC)*

Journal of Biological Chemistry, 2016
The epithelial sodium channel (ENaC) is the limiting entry point for Na+ reabsorption in the distal kidney nephron and is regulated by numerous hormones, including the mineralocorticoid hormone aldosterone.
C. Klemens, R. Edinger, Lindsay Kightlinger, Xiaoning Liu, M. Butterworth   +4 more
semanticscholar   +1 more source

Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells.

PLoS ONE
The airway epithelium plays a pivotal role in regulating mucosal immunity and inflammation. Epithelial barrier function, homeostasis of luminal fluid, and mucociliary clearance are major components of mucosal defense mechanisms.
Anusree Sasidharan, Astrid Grosche, Xiaodong Xu, T Bernard Kinane, Damiano Angoli, Sadasivan Vidyasagar   +5 more
doaj   +1 more source

Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease

The Journal of Medical Investigation, 2009
ber of the ENaC/degenerin family of non-voltage gated ion channels. ENaC is localized in the apical membrane of epithelial cells, and is the rate limiting step for sodium absorption in a number of epithelial tissues like the aldosterone-sensitive distal nephron (ASDN), respiratory epithelia, distal colon, sweat and salivary ducts.
openaire   +3 more sources

Steroid regulation of epithelial sodium channels (ENaC) in mammary epithelial cells

The FASEB Journal, 2006
The epithelial sodium channel (ENaC) is important in lactating mammary cells for regulating the Na + content of milk, while in cancerous mammary cells ENaC may play a role in oncogenesis. The goal of this study is to determine how steroids and/or the serum‐and glucocorticoid induced kinase ...
Cary R Boyd, Aniko Naray‐Fejes‐Toth
openaire   +1 more source

δ-Subunit Confers Novel Biophysical Features to αβγ-Human Epithelial Sodium Channel (ENaC) via a Physical Interaction*

Journal of Biological Chemistry, 2006
Native amiloride-sensitive Na+ channels exhibit a variety of biophysical properties, including variable sensitivities to amiloride, different ion selectivities, and diverse unitary conductances.
H. Ji, X. Su, Shrestha Kedar, Jie Li, P. Barbry, Peter R. Smith, S. Matalon, D. Benos   +7 more
semanticscholar   +1 more source

Sodium selectivity of semicircular canal duct epithelial cells

BMC Research Notes, 2011
Background Sodium absorption by semicircular canal duct (SCCD) epithelial cells is thought to contribute to the homeostasis of the volume of vestibular endolymph.
Harbidge Donald G, Pondugula Satyanarayana R, Wu Tao, Yamazaki Muneharu, Marcus Daniel C   +4 more
doaj   +1 more source

Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

Respiratory Research, 2010
Background Hyperactivity of the epithelial sodium (Na+) channel (ENaC) and increased Na+ absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the ...
Clerici Christine, Prulière-Escabasse Virginie, Vuagniaux Grégoire, Coste Andre, Escudier Estelle, Planès Carole   +5 more
doaj   +1 more source

A variant of ASIC2 mediates sodium retention in nephrotic syndrome

JCI Insight, 2021
Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC) activation after plasma aldosterone increase.
Marc Fila, Ali Sassi, Gaëlle Brideau, Lydie Cheval, Luciana Morla, Pascal Houillier, Christine Walter, Michel Gennaoui, Laure Collignon, Mathilde Keck, Gabrielle Planelles, Naziha Bakouh, Michel Peuchmaur, Georges Deschênes, Ignacio Anegon, Séverine Remy, Bruno Vogt, Gilles Crambert, Alain Doucet   +18 more
doaj   +1 more source