Structure of the human epithelial sodium channel by cryo-electron microscopy
eLife, 2018 The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na+ and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel.
Sigrid Noreng +4 more
doaj +1 more source
The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells
Cells, 2021 The SCN4B gene, coding for the NaVβ4 subunit of voltage-gated sodium channels, was recently found to be expressed in normal epithelial cells and down-regulated in several cancers.
Adélaïde Doray +10 more
doaj +1 more source
Antifibrotic Drugs Regulate the Expression of Epithelial Sodium Channels in the Lungs
Advances in Respiratory MedicinePurpose: A high-salt extracellular environment promotes fibrosis in multiple organs by inducing oxidative stress, fibroblast activation, and extracellular matrix remodeling.
Toshiyuki Ito +13 more
doaj +1 more source
Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines
Frontiers in Immunology, 2017 Acute lung injury leading to acute respiratory distress (ARDS) is a global health concern. ARDS patients have significant pulmonary inflammation leading to flooding of the pulmonary alveoli. This prevents normal gas exchange with consequent hypoxemia and
Brandi M. Wynne +11 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
core +1 more source
In vivo phosphorylation of the epithelial sodium channel [PDF]
Proceedings of the National Academy of Sciences, 1998 The activity of the epithelial sodium channel (ENaC) in the distal nephron is regulated by an antidiuretic hormone, aldosterone, and insulin, but the molecular mechanisms that mediate these hormonal effects are mostly unknown. We have investigated whether aldosterone, insulin, or activation of protein kinases has an effect on the ...
R A, Shimkets, R, Lifton, C M, Canessa
openaire +2 more sources
Epithelial sodium channel, salt intake, and hypertension. [PDF]
, 2003 The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron.
Hummler, E.
core +1 more source
Role of Epithelial Sodium Channels and Their Regulators in Hypertension [PDF]
Journal of Biological Chemistry, 2010 The kidney has a central role in the regulation of blood pressure, in large part through its role in the regulated reabsorption of filtered Na(+). Epithelial Na(+) channels (ENaCs) are expressed in the most distal segments of the nephron and are a target of volume regulatory hormones.
Rama, Soundararajan +3 more
openaire +2 more sources
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]
, 2009 In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N. +5 more
core +1 more source
The Saudi Journal of Gastroenterology, 2015 Background/Aim: Aerobic metabolism is necessary for ion transport in many transporting epithelia, including the human colonic epithelium. We assessed the effects of the epithelial sodium channel blocker, amiloride, on oxygen consumption and short-circuit
Graciela E Carra +3 more
doaj +1 more source