Results 31 to 40 of about 71,499 (299)

Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel–Mediated Intestinal Sodium Absorption and Blood Pressure Regulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Mineralocorticoid receptor (MR) has pathological roles in various cell types, including renal tubule cells, myocytes, and smooth muscle cells; however, the role of MR in intestinal epithelial cells (IECs) has not been sufficiently evaluated ...
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai‐Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Yukiko Minami, Hirotaka Shibata, Hiroshi Itoh   +11 more
doaj   +1 more source

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987)   +14 more
core   +1 more source

Could a defective epithelial sodium channel lead to bronchiectasis

Respiratory Research, 2008
Background Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified.
Hubert Dominique, Sublemontier Sébastien, Viel Marion, Fajac Isabelle, Bienvenu Thierry   +4 more
doaj   +1 more source

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. [PDF]

, 2013
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett, Tarran Robert, Ward, Christopher, Ward Christopher, Michael A Gray, Baines, DL, Garnett, James P., Robert Tarran, Christopher Ward, Ward, C, Garnett, JP, Baker, EH, Brodlie Malcolm, Baker, Emma H., Tarran, Robert, Gray Michael A., Brodlie, Malcolm, Baker Emma H., Garnett James P., Brodlie, M, Deborah L Baines, Baines Deborah L., Gray, Michael A., Baines, Deborah L., Gray, MA, Malcolm Brodlie, Tarran, R, Emma H Baker   +27 more
core   +2 more sources

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Cell‐Specific Actions of the Prostaglandin E‐Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension.
Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman   +7 more
doaj   +1 more source

The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes [PDF]

, 2013
Cellular directional migration in an electric field (galvanotaxis) is one of the mechanisms guiding cell movement in embryogenesis and in skin epidermal repair.
Isseroff, R. Rivkah, Charles, Roch-Philippe, Baines, Deborah L., Hummler, Edith, Yang, Hsin-Ya   +4 more
core   +1 more source

The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis

Biomedicines, 2022
The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases (WNK1-4), were first linked to hypertension due to their mutations in association with pseudohypoaldosteronism type II (PHAII).
Shiuan-Chen Lin, Chun Ma, Kao-Jung Chang, Han-Ping Cheong, Ming-Cheng Lee, Yuan-Tzu Lan, Chien-Ying Wang, Shih-Hwa Chiou, Teh-Ia Huo, Tsui-Kang Hsu, Ping-Hsing Tsai, Yi-Ping Yang   +11 more
doaj   +1 more source

Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel

Scientific Reports, 2021
Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz, Antonio G. Soares, Elena Mironova, Nina Boiko, Amanpreet Kaur, Crystal R. Archer, James D. Stockand, Jonathan M. Berman   +7 more
doaj   +1 more source

Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells [PDF]

International Journal of Biological Sciences, 2016
Regeneration of the epithelium of mammalian lungs is essential for restoring normal function following injury, and various cells and mechanisms contribute to this regeneration and repair. Club cells, bronchioalveolar stem cells (BASCs), and alveolar type II epithelial cells (ATII) are dominant stem/progenitor cells for maintaining epithelial turnover ...
Liu, Yang, Jiang, Bi-Jie, Zhao, Run-Zhen, Ji, Hong-Long   +3 more
openaire   +2 more sources