Results 1 to 10 of about 16,803 (187)
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 2020 Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and ...
Peter S Sever
exaly +4 more sources
Lithium‐induced kidney injury and fibrosis: A versatile model to explore cellular pathways of injury and repair [PDF]
Physiological ReportsLithium‐induced kidney injury is commonly associated with the development of nephrogenic diabetes insipidus. Longer term lithium exposure is associated with the development of chronic interstitial fibrosis. The mechanisms of lithium‐induced kidney injury
Paulomi Mehta +2 more
doaj +2 more sources
Frontiers in Physiology, 2021 Acid-Sensing Ion Channels (ASICs) are proton-gated sodium-selective cation channels that have emerged as metabolic and pain sensors in peripheral sensory neurons and contribute to neurotransmission in the CNS.
Daniel S. Matasic +18 more
doaj +1 more source
Molecules, 2022 THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC)
Maria Mernea +7 more
doaj +1 more source
Reduction of lithium induced interstitial fibrosis on co-administration with amiloride
Scientific Reports, 2022 Long-term administration of lithium is associated with chronic interstitial fibrosis that is partially reduced with exposure to amiloride. We examined potential pathways of how amiloride may reduce interstitial fibrosis.
Paulomi M. Mehta +3 more
doaj +1 more source
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]
PLoS ONE, 2011 Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang +9 more
doaj +1 more source
6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist
Biomolecules, 2022 P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson +12 more
doaj +1 more source
Biomedicines, 2022 Objective: Current treatments for blast-induced lung injury are limited to supportive procedures including mechanical ventilation. The study aimed to investigate the role of post-trauma-induced oedema generation in the function of time and trauma ...
Hanno Huwer +9 more
doaj +1 more source
Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs
Frontiers in Cellular and Infection Microbiology, 2023 Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance.
Kiem Vu +9 more
doaj +1 more source
Physiological Reports, 2022 The maintenance of endothelial health is required for normal vascular function and blood pressure regulation. The epithelial Na+ channel (ENaC) in endothelial cells has emerged as a new molecular player in the regulation of endothelial nitric oxide ...
Stephanie M. Mutchler, Thomas R. Kleyman
doaj +1 more source