Results 11 to 20 of about 16,803 (187)

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Essigke D, Kalo MZ, Wörn M, Li XQ, Bohnert BN, Schork A, Birkenfeld AL, Ott T, Artunc F.   +8 more
europepmc   +2 more sources

Tumour-Derived Extracellular Vesicles Induce Diffuse Large B-Cell Lymphoma Progression Through Macrophage-Mediated MDSC Accumulation. [PDF]

J Extracell Vesicles
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Liu M, Dong Y, Guan Q, Wang J, Shi Q, Lin R, Zhang M, Fu D, Cheng S, Xu P, Angeli E, Bousquet G, Cui W, Dou H, Zhao WL, Wang L.   +15 more
europepmc   +2 more sources

Stability of extemporaneously compounded amiloride nasal spray.

PLoS ONE, 2020
Anxiety disorders (AD) are the most common mental conditions affecting an estimated 40 million adults in the United States. Amiloride, a diuretic agent, has shown efficacy in reducing anxious responses in preclinical models by inhibiting the acid-sensing
Venkata Yellepeddi, Casey Sayre, Anna Burrows, Kevin Watt, Simon Davies, John Strauss, Marco Battaglia   +6 more
doaj   +1 more source

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

Skeletal Muscle, 2021
Background Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments.
Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang, Donghai Lin   +12 more
doaj   +1 more source

The Antifungal Activity of HMA, an Amiloride Analog and Inhibitor of Na+/H+ Exchangers

Frontiers in Microbiology, 2021
One path toward identifying effective and easily accessible antifungals is to repurpose commonly used drugs. Amiloride, a widely used diuretic, inhibits different isoforms of Na+/H+ exchangers, Na+ channels, and Na+/Ca2+ exchangers.
Kiem Vu, Eduardo Blumwald, Angie Gelli
doaj   +1 more source

Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. [PDF]

PLoS Pathogens, 2010
In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride.
Laura I Levi, Nina F Gnädig, Stéphanie Beaucourt, Malia J McPherson, Bruno Baron, Jamie J Arnold, Marco Vignuzzi   +6 more
doaj   +1 more source

Bioactive Molecules against Rheumatoid Arthritis by Suppressing Pyroptosis

Pharmaceuticals, 2023
Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death associated with an inflammatory response. Pyroptosis, which occurs in synovial and osteoblastic cells, can exacerbate the development of rheumatoid arthritis.
Qian Zhou, Tian Li, Gang Fang, Yuzhou Pang, Xueni Wang   +4 more
doaj   +1 more source

Pathogenicity and Long-Term Outcomes of Liddle Syndrome Caused by a Nonsense Mutation of SCNN1G in a Chinese Family

Frontiers in Pediatrics, 2022
ObjectiveLiddle syndrome (LS) is a monogenic hypertension consistent with autosomal dominant inheritance, often with early onset high blood pressure in childhood or adolescence.
Di Zhang, Yi Qu, Xue-Qi Dong, Yi-Ting Lu, Kun-Qi Yang, Xin-Chang Liu, Peng Fan, Yu-Xiao Hu, Chun-Xue Yang, Ling-Gen Gao, Ya-Xin Liu, Xian-Liang Zhou   +11 more
doaj   +1 more source

Trial of Amiloride in Type 2 Diabetes With Proteinuria

Kidney International Reports, 2017
Renal sodium (Na+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na+ transporters. Plasmin-dependent activation of the epithelial Na+
Mark L. Unruh, V. Shane Pankratz, John E. Demko, Evan C. Ray, Rebecca P. Hughey, Thomas R. Kleyman   +5 more
doaj   +1 more source

Study of Amiloride Binding to Human Serum Albumin: Insights from Thermodynamic, Spectroscopic, and Molecular Docking Investigations

Molecules, 2023
This study was undertaken to investigate the interaction between the sodium channel blocker amiloride (AML) and human serum albumin (HSA). A combination of multi-spectroscopic techniques and computational methods were employed to identify the AML binding
Safikur Rahman, Sana Iram, Md Tabish Rehman, Afzal Hussain, Arif Tasleem Jan, Jihoe Kim   +5 more
doaj   +1 more source