Results 21 to 30 of about 16,803 (187)
A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. [PDF]
PLoS ONE, 2013 Amiloride is a potassium-sparing diuretic that has been used as an anti-kaliuretic for the chronic management of hypertension and heart failure. Several studies have identified a potential anti-cancer role for amiloride, however the mechanisms underlying
Leonardo J Leon +3 more
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Animals, 2022 Acute-stress situations in vertebrates induce a series of physiological responses to cope with the event. While common secondary stress responses include increased catabolism and osmoregulatory imbalances, specific processes depend on the taxa.
Ignacio Ruiz-Jarabo +5 more
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Pharmacokinetics of intranasal amiloride in healthy volunteers
Clinical and Translational Science, 2023 Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid‐sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and ...
Venkata K. Yellepeddi +10 more
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Frontiers in Physiology, 2022 Primary hyperaldosteronism (PA) is characterized by aldosterone excess and hypertension. This may be linked to increased renal Na+ reabsorption via the epithelial Na+ channel (ENaC) and the NaCl cotransporter (NCC).
Mathias Kristensen +2 more
doaj +1 more source
Synthesis, characterization and investigation of biodistribution of dendrimer-amiloride nanoconjugate using single photon computed tomography technique in animal sample [PDF]
Nanomedicine JournalObjective(s): Amiloride is a pyrazine compound that inhibits the reabsorption of sodium by blocking sodium channels in the cells of the renal cortex. It has demonstrated promising efficacy in the treatment of cancer in recent times.
Sheida Iranpour +5 more
doaj +1 more source
Circulation, 1968 Amiloride, a new, well-tolerated oral natriuretic and mild diuretic agent, has been evaluated alone and in combination with other diuretics. Its remarkable ability to promote retention rather than loss of potassium makes it a useful adjunct in the management of even the most severe edematous states.
M B, Bull, J H, Laragh
openaire +2 more sources
Clinical and Experimental Hypertension, 2019 We sought to determine the effect of amiloride on blood pressure (BP) and the presence of polymorphisms of the β-subunit of the epithelial sodium channel (ENaC) among normotensive (NT) and hypertensive (HT) Nigerians.
Simiat O. Elias +2 more
doaj +1 more source
Nephrotic Syndrome: Oedema Formation and Its Treatment With Diuretics
Frontiers in Physiology, 2019 Oedema is a defining element of the nephrotic syndrome. Its’ management varies considerably between clinicians, with no national or international clinical guidelines, and hence variable outcomes.
Sanjana Gupta +4 more
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iScienceSummary: The kidney is a vital organ responsible for water and sodium metabolism, while the primary function of amiloride is to promote the excretion of water and sodium. We investigated amiloride enhanced the sunitinib sensitivity in RCC.
Yuanyuan Bai +10 more
doaj +1 more source
Regulation of nephron acidification by corticosteroids
Brazilian Journal of Medical and Biological Research, 1997 The present paper reviews work from our laboratories evaluating the importance of adrenal cortical hormones in acidification by proximal and cortical distal tubules.
G. Malnic +3 more
doaj +1 more source