Results 61 to 70 of about 71,499 (299)

Amiloride-Sensitive Sodium Channels and Pulmonary Edema

Pulmonary Medicine, 2011
The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance.
Mike Althaus, Wolfgang G. Clauss, Martin Fronius   +2 more
doaj   +1 more source

NaHS or Lovastatin Attenuates Cyclosporine A–Induced Hypertension in Rats by Inhibiting Epithelial Sodium Channels

Frontiers in Pharmacology, 2021
The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron cells.
Qiu-Shi Wang, Qiu-Shi Wang, Chen Liang, Shuai Jiang, Di Zhu, Yu Sun, Na Niu, Xu Yang, Yan-Chao Yang, Bi-Han Dong, Jie Yao, Chang-Jiang Yu, Jie Lou, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma   +16 more
doaj   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Foulkes, T, Baker, MD, Matthews, EA, Gerke, V, Lane, T, Wood, JN, Okuse, K, Nassar, MA, Dickenson, AH   +8 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Physiologic regulation of the epithelial sodium channel by phosphatidylinositides [PDF]

Current Opinion in Nephrology and Hypertension, 2008
Epithelial sodium channel (ENaC) activity is limiting for sodium reabsorption in the distal nephron. Humans regulate blood pressure by fine-tuning sodium balance through control of ENaC. ENaC dysfunction causes some hypertensive and renal salt wasting diseases. Thus, it is critical to understand the cellular mechanisms controlling ENaC activity.ENaC is
Oleh, Pochynyuk, Vladislav, Bugaj, James D, Stockand   +2 more
openaire   +2 more sources

(Pro)Renin receptor mediates obesity-induced antinatriuresis and elevated blood pressure via upregulation of the renal epithelial sodium channel. [PDF]

PLoS ONE, 2018
Recent studies have demonstrated that the renal (pro)renin receptor (PRR) regulates expression of the alpha subunit of the epithelial sodium channel (α-ENaC).
Syed S Quadri, Silas Culver, Nrupama Ramkumar, Donald E Kohan, Helmy M Siragy   +4 more
doaj   +1 more source

Peripheral localization of the epithelial sodium channel (ENaC) in the apical membrane of bronchial epithelial cells [PDF]

, 2019
What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance?
Musante I, Guidone D, Castellani S., Venturini A, Galietta LJV., Scudieri P., Venturini A., Caci E., Scudieri P, Caci E, Conese M., Castellani S, Musante I., Guidone D., Galietta L. J. V., Conese M   +15 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport

Frontiers in Pharmacology
IntroductionWuji Wan (WJW) is a classical Chinese formula traditionally prescribed for diarrhea/dysentery and abdominal pain. In ulcerative colitis (UC), inflammatory diarrhea reflects not only mucosal inflammation but also inflammation-linked disruption
Jianyu Zhang, Yang Zhang, Yuxuan Guo, Yi Sun, Yujie Li, Qi Li, Ying Chen, Yajie Wang, Qing Yang, Meiyu Zhang, Xiaogang Weng, Zhihao Deng   +11 more
doaj   +1 more source

Effect of epithelial sodium channel blockade in hypertensive Nigerians [PDF]

, 2012
Background: Approximately 60% of hypertensive Nigerians are salt-sensitive. The demonstration of genetic linkage between Liddle syndrome and epithelial sodium channel (ENaC) suggests the physiological involvement of ENaC in blood pressure regulation ...
Elias, Simiat, Sofola, Soga, Jaja, Smith
core   +1 more source