Results 71 to 80 of about 71,499 (299)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Characterization of the Selectivity Filter of the Epithelial Sodium Channel [PDF]

Journal of Biological Chemistry, 2000
The epithelial sodium channel (ENaC) is composed of three homologous subunits termed alpha, beta, and gamma. Previous studies suggest that selected residues within a hydrophobic region immediately preceding the second membrane-spanning domain of each subunit contribute to the conducting pore of ENaC.
S, Sheng, J, Li, K A, McNulty, D, Avery, T R, Kleyman   +4 more
openaire   +2 more sources

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Regulation of Epithelial Sodium Channel Trafficking by Ubiquitination [PDF]

Proceedings of the American Thoracic Society, 2010
Abstract Amiloride-sensitive epithelial sodium (Na+) channels (ENaC) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of channels on the apical surface of ...
Douglas C, Eaton, Bela, Malik, Hui-Fang, Bao, Ling, Yu, Lucky, Jain   +4 more
openaire   +2 more sources

Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit. [PDF]

, 2008
OBJECTIVE: The aim of the study was to search for mutations of SCNN1B and SCNN1G in an Italian family with apparently dominant autosomal transmission of a clinical phenotype consistent with Liddle's syndrome.
FARNETTI E, Nicoli, D., Negro, A., Grasselli, C., Debonneville, A., PERAZZOLI F, Regolisti, G., Staub, O., GRASSELLI C, CASALI B, STAUB O., Farnetti, E., ROSSI E, Casali, B., Mantero, F., NICOLI D, DEBONNEVILLE A, NEGRO A, Rossi, E., REGOLISTI G, MANTERO, FRANCO, Perazzoli, F.   +21 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Rab Proteins Regulate Epithelial Sodium Channel Activity in Colonic Epithelial HT-29 Cells [PDF]

, 2005
ENaC, the sodium-selective amiloride-sensitive epithelial channel, mediates electrogenic sodium re-absorption in tight epithelia and is deeply associated with human hypertension.
Singh, Madhurima, Kaur, Simarna, Fukuda, Mitsunori, Saxena, Sunil, Engisch, Kathrin L.   +4 more
core   +1 more source

Myrcene‐Based Tailored Co‐Polymers as Active Pharmaceutical Excipients: Bio‐Based Solutions for Mucoadhesive Excipients

Advanced Functional Materials, EarlyView.
Mucoadhesive amphiphilic block and statistical copolymers were synthesized via Reversible Addition–Fragmentation Chain Transfer polymerization from bio‐sourced myrcene and polyethylene glycol methacrylate. The resulting polymers exhibit narrow molar‐mass distributions, high regioselectivity, well‐defined microstructures, and tend to self‐assemble into ...
David Gintsburg, Selin Görkem Sari, Lana Molnar, Annabelle Knoll, Effrosyni‐Maria Kosti, Anna Seybold, Gozde Deveci, Nico Bruns, Andreas Bernkop‐Schnürch, Gergely Kali   +9 more
wiley   +1 more source

Number of Subunits Comprising the Epithelial Sodium Channel [PDF]

Journal of Biological Chemistry, 1999
The human epithelial sodium channel (hENaC) is a hetero-oligomeric complex composed of three subunits, alpha, beta, and gamma. Understanding the structure and function of this channel and its abnormal behavior in disease requires knowledge of the number of subunits that comprise the channel complex.
S, Eskandari, P M, Snyder, M, Kreman, G A, Zampighi, M J, Welsh, E M, Wright   +5 more
openaire   +2 more sources

The role of the epithelial Na+ channel (ENaC) in high AVP but low aldosterone states

Frontiers in Physiology, 2012
Due to the abundance of seminal discoveries establishing a strong causal relation between changes in aldosterone signaling, the activity of the epithelial Na+ channel (ENaC) and blood pressure, the role of ENaC in health and disease is understood almost ...
James D Stockand
doaj   +1 more source