Results 181 to 190 of about 22,476 (217)

Regulation of the epithelial sodium channel (ENaC) by membrane trafficking

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2010
The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a number of epithelial tissues. Abnormalities in ENaC function have been directly linked to several human disease states including Liddle syndrome ...
Michael B Butterworth
exaly   +2 more sources

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The role of ENaC in vascular endothelium

Pflugers Archiv European Journal of Physiology, 2013
Once upon a time, the expression of the epithelial sodium channel (ENaC) was mainly assigned to the kidneys, colon and sweat glands where it was considered to be the main determinant of sodium homeostasis. Recent, though indirect, evidence for the possible existence of ENaC in a non-epithelial tissue was derived from the observation that the vascular ...
Kristina Kusche-Vihrog, Pia Jeggle, Hans Oberleithner   +2 more
exaly   +3 more sources

Control of ENaC ubiquitination

American Journal of Physiology-Renal Physiology
We have explored the mechanisms underlying the ubiquitination of the γ subunit of epithelial Na+ channel (ENaC), a process believed to control channel internalization and degradation. We previously reported that the mature, cleaved form of the subunit is selectively ubiquitinated.
Shujie Shi, Gustavo Frindt, Sarah Christine M. Whelan, Lawrence G. Palmer   +3 more
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Nongenomic regulation of ENaC by aldosterone

American Journal of Physiology-Cell Physiology, 2001
Aldosterone is involved in salt and water homeostasis. The main effect is thought to involve genomic mechanisms. However, the existence of plasma membrane steroid receptors has been postulated. We used whole cell patch clamp to test the hypothesis that epithelial sodium channels (ENaC) expressed by renal collecting duct principal cells can be regulated
Z H, Zhou, J K, Bubien
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ENaC Modulators and Renal Disease

Current Molecular Pharmacology, 2013
The epithelial sodium channel (ENaC) plays an essential role in transepithelial sodium reabsorption in the renal connecting tubule and collecting duct. Therefore, controlling ENaC activity is an important regulatory event in electrolyte and extracellular volume homeostasis, and thus in the control of blood pressure.
Diego, Alvarez de la Rosa, Juan F, Navarro-González, Teresa, Giraldez   +2 more
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Inhibition of ENaC by intracellular Cl⁻in an MDCK clone with high ENaC expression

American Journal of Physiology-Renal Physiology, 2004
We examined the effects of intracellular Cl−concentration ([Cl−]i) on the epithelial Na channel (ENaC) in a line of Madin-Darby canine kidney (MDCK) cells (FL-MDCK) with a high rate of Na+transport produced by stable retroviral transfection with rENaC subunits (Morris RG and Schafer JA. J Gen Physiol 120: 71–85, 2002). Treatment with cAMP (100 μM 8-cpt-
Yi, Xie, James A, Schafer
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Kinases as Targets for ENaC Regulation

Current Molecular Pharmacology, 2013
Amiloride-sensitive epithelial sodium channels (ENaCs) transport Na+ and are essential for salt and fluid homeostasis across epithelial tissues. Several pathological conditions of renal and pulmonary tissues are associated with abnormal ENaC function. The signalling pathways that regulate ENaC activity utilise a number of kinases.
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Epithelial Sodium Channels (ENaCs)

2015
Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Mechanosensation and the DEG/ENaC Ion Channels

Science, 1996
Cloning of a new protein that participates in mechanosensation in Caenorhabditis elegans (see J. Liu et al ., p. 361 ) prompts this Perspective's discussion of the superfamily of ion channels that underlie this receptive process and the parallels between ...
D P, Corey, J, García-Añoveros
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Inhibiting ENaC Activation

Science Signaling, 2008
Proteolytic activation of epithelial sodium channels is inhibited by increased intracellular sodium.
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