Results 51 to 60 of about 663,455 (279)

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Recurrent herpes simplex virus encephalitis with presumptive Human Herpesvirus 6 chromosomal integration

IDCases, 2023
Viral encephalitis can lead to encephalopathy, epileptic activity, focal neurological deficits, and death. Prompt recognition and a high index of clinical suspicion can lead to early initiation of appropriate management.
Claire Allen, Shiavax J. Rao, Kavneet Gill, Marcos Wolff, Christopher J. Haas   +4 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children

Детские инфекции (Москва), 2020
Purulent meningitis and viral encephalitis are the most common neuroinfections in children. The severity of the lesion, the frequency of disabling manifestations, as well as high mortality, determine the relevance of their study. Violations of hemostasis
E. S. Egorova, N. V. Skripchenko, А. А. Vilnits, L. A. Alekseeva, E. Yu. Skripchenko   +4 more
doaj   +1 more source

Prognostic factors of subacute comprehensive encephalitis: a retrospective study [PDF]

Purpose The etiology of encephalitis is unknown in 40%–50% of cases, so a comprehensive examination of encephalitis would be significant and meaningful. The short-term outcomes in appropriately managed patients are also unknown.
Hitoki Nanaura, Hiroshi Kataoka, Kazuma Sugie   +2 more
core   +2 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

PREVALENCE OF HEPATITIS E MARKERS IN CHILDREN

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status. Materials and methods.
I. A Potemkin, M. A Lopatukhina, O. A Gadzhieva, E. L Prokhorova, A. Diyarrassuba, O. V Isaeva, T. V Kozhanova, O. E Ivanova, O. V Silenova, N. Kh Setdikova, K. K Kyuregyan, M. I Mikhailov   +11 more
doaj  

Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer

Vaccines
Objective: We evaluate the immunotherapeutic potential of the yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy of pancreatic cancer in mice.
Alina S. Nazarenko, Yulia K. Biryukova, Kirill N. Trachuk, Ekaterina A. Orlova, Mikhail F. Vorovitch, Nikolay B. Pestov, Nick A. Barlev, Anna I. Levaniuk, Ilya V. Gordeychuk, Alexander S. Lunin, Grigory A. Demyashkin, Petr V. Shegai, Andrei D. Kaprin, Aydar A. Ishmukhametov, Nadezhda M. Kolyasnikova   +14 more
doaj   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source