Results 31 to 40 of about 58,138 (49)

Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids

Cell Death and Disease, 2018
Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world’s public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon ...
Boya Zhang, Yangzhige He, Yan-Peng Xu, Fan Mo, Ting-Wei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, C. Qin, Baoyang Hu, Guomin Zhou   +14 more
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Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Emerging Infectious Diseases, 2018
Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in
V. Cheng, S. Sridhar, Shuk-Ching Wong, S. C. Wong, J. Chan, C. Yip, C. Chau, Timmy W. K. Au, Y. Hwang, Carol S.W. Yau, J. Lo, Cheuk-Kwong Lee, K. Yuen   +12 more
semanticscholar   +1 more source

TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection

Viruses, 2018
Japanese encephalitis virus (JEV) is a mosquito-borne Flavivirus, the leading cause of viral-induced encephalitis. Several host molecules have been identified as the JEV attachment factor; however, the molecules involved in JEV entry remain poorly ...
Jichen Niu, Ya Jiang, Hao Xu, Changjing Zhao, Guodong Zhou, Pu-yan Chen, Ruibing Cao   +6 more
semanticscholar   +1 more source

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells

Journal of Virology, 2017
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the leading cause of viral encephalitis in Southeast Asia with potential to become a global pathogen.
Minu Nain, Minu Nain, S. Mukherjee, Sonali Porey Karmakar, Andrienne W. Paton, J. Paton, M. Abdin, A. Basu, Manjula Kalia, S. Vrati   +9 more
semanticscholar   +1 more source

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Nature Communications, 2017
Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia.
Xiangxi Wang, Shihua Li, Ling Zhu, Qinggong Nian, S. Yuan, Q. Gao, Zhong-yu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, N. Shaw, Junzhi Wang, T. Walter, J. Huiskonen, E. Fry, C. Qin, D. Stuart, Z. Rao   +17 more
semanticscholar   +1 more source

Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage

Journal of Neuroinflammation, 2018
Overstimulation of glutamate receptors, especially neuronal N-methyl-d-aspartate receptor (NMDAR), mediates excitatory neurotoxicity in multiple neurodegenerative diseases. However, the role of NMDAR in the regulation of Japanese encephalitis virus (JEV)-
Zheng Chen, Xugang Wang, U. Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, S. Cao   +10 more
semanticscholar   +1 more source

Vector-free transmission and persistence of Japanese encephalitis virus in pigs

Nature Communications, 2016
Japanese encephalitis virus (JEV), a main cause of severe viral encephalitis in humans, has a complex ecology, composed of a cycle involving primarily waterbirds and mosquitoes, as well as a cycle involving pigs as amplifying hosts.
M. Ricklin, O. García-Nicolás, D. Brechbühl, S. Python, B. Zumkehr, A. Nougairède, R. Charrel, H. Posthaus, A. Oevermann, A. Summerfield   +9 more
semanticscholar   +1 more source

Targeting of the Nasal Mucosa by Japanese Encephalitis Virus for Non-Vector-Borne Transmission

Journal of Virology, 2018
JEV, a main cause of severe viral encephalitis in humans, has a complex ecology composed of a mosquito-waterbird cycle and a cycle involving pigs, which amplifies virus transmission to mosquitoes, leading to increased human cases.
O. García-Nicolás, R. O. Braun, P. Milona, M. Lewandowska, R. Dijkman, M. Alves, A. Summerfield   +6 more
semanticscholar   +1 more source

Comparison of the dynamics of Japanese encephalitis virus circulation in sentinel pigs between a rural and a peri-urban setting in Cambodia

PLoS Neglected Tropical Diseases, 2018
Japanese encephalitis is mainly considered a rural disease, but there is growing evidence of a peri-urban and urban transmission in several countries, including Cambodia.
J. Di Francesco, Rithy Choeung, Borin Peng, Long Pring, S. Pang, R. Duboz, Sivuth Ong, S. Sorn, A. Tarantola, D. Fontenille, V. Duong, P. Dussart, V. Chevalier, J. Cappelle   +13 more
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Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus

mBio, 2018
Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited.
Estefania Fernandez, Nurgun Kose, M. Edeling, J. Adhikari, G. Sapparapu, Susana M. Lazarte, C. Nelson, Jennifer Govero, M. Gross, D. Fremont, J. Crowe, M. Diamond   +11 more
semanticscholar   +1 more source