Results 121 to 130 of about 447,569 (400)
Bioprinted Constructs in the Regulatory Landscape: Current State and Future Perspectives
Advanced Materials, EarlyView.Bioprinting has rapidly emerged as a transformative technology in biomedical research, offering unprecedented potential to replicate complex tissues. Despite its promise, clinical translation remains limited due to regulatory hurdles. This review explores global regulatory frameworks, comparing approaches in the EU, U.S., China, and Australia, and ...
Francesca Perin +6 more
wiley +1 more source
Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study [PDF]
, 2008 The aim of this study was to analyze molecular features of protease-resistant prion protein (PrPres) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status.
Jacobs, J.G. +3 more
core +1 more source
Posterior reversible encephalopathy syndrome
Journal of Neurology, 2017 The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness,
Marlene Fischer, E. Schmutzhard
semanticscholar +1 more source
Biocompatible Ink Optimization Enables Functional Volumetric Bioprinting With Xolography
Advanced Materials, EarlyView.Xolography's reliance on weak‐base co‐initiators introduces unique biochemical constraints. By dissecting the effects of extracellular pH, osmolality, and lysosomotropic stress, this study defines the biochemical design space that enables fully biocompatible, cell‐laden volumetric printing. Abstract Xolography is a novel linear volumetric manufacturing
Erik Brauer +17 more
wiley +1 more source
Kaohsiung Journal of Medical Sciences, 2017 The aim of this meta-analysis was to detect whether three identified single nucleotide polymorphisms (SNPs) (rs646776, rs599839, and rs17465637) at 1p13.3 and 1q41 are associated with lipid levels and the risk of coronary artery disease (CAD).
Qian-Chao He +8 more
doaj +1 more source
Sex Differences in the Association Between Frailty and Sarcopenia in Patients With Cirrhosis. [PDF]
, 2019 ObjectivesFrailty is prevalent in patients with cirrhosis and is hypothesized to result in part from sarcopenia, but the precise contribution of sarcopenia to frailty in this population is poorly understood.MethodsIncluded were patients with cirrhosis ...
Bhanji +17 more
core +2 more sources
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Several members of the tripartite motif-containing (TRIM) protein family have been reported to serve as vital regulators of tumorigenesis. Recent studies have demonstrated an oncogenic role of TRIM 14 in multiple human cancers; however, the ...
Shuang Feng +5 more
doaj +1 more source
"Electro-clinical Syndromes" with onset in Paediatric Age. the highlights of the clinical-EEG, genetic and therapeutic advances [PDF]
, 2011 The genetic causes underlying epilepsy remain largely unknown, and the impact of available genetic data on the nosology of epilepsy is still limited.
Alberto Verrotti +7 more
core +2 more sources
Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, EarlyView.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source