Results 31 to 40 of about 341,645 (314)

Antidepressant-Like Effect of Geniposide in Mice Exposed to a Chronic Mild Stress Involves the microRNA-298-5p-Mediated Nox1

Frontiers in Molecular Neuroscience, 2021
Depression is a common mental disorder that presents a considerable challenge for public health. The natural product geniposide has neuroprotective effects on depression, but the underlying mechanism behind these effects had remained undefined.
Tianyu Zou, Jielin Zhang, Yongxiu Liu, Yiming Zhang, Kazuo Sugimoto, Cheng Mei   +5 more
doaj   +1 more source

Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Frontiers in Endocrinology, 2022
Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact ...
Tingting Wang, Limin Wu, Qiuying Chen, Kuiyu Chen, Fang Tan, Jiabo Liu, Xiang Liu, Hui Han   +7 more
doaj   +1 more source

Neurological consequences of traumatic brain injuries in sports. [PDF]

, 2015
Traumatic brain injury (TBI) is common in boxing and other contact sports. The long term irreversible and progressive aftermath of TBI in boxers depicted as punch drunk syndrome was described almost a century ago and is now widely referred as chronic ...
Hardy, J, Ling, H, Zetterberg, H
core   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease

Scientific Reports, 2023
Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear.
Dan Wang, Daojun Xie, Juan Zhang, Biao Cai, Bo Yang, Lei Zhou, Xiaofeng Huang   +6 more
doaj   +1 more source

Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]

, 1999
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Hammer, C., Heil, W., Lemmens, H.-P., Matthes, M., Neuhaus, P., Padval, D., Puhl, G., Schön, M. R.   +7 more
core   +1 more source

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]

, 2005
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson, Annane, Astudillo, Barie, Barie, Bastos, Bertsch, Blomquist, Bollaert, Bolton, Bolton, Bone, Briegel, Briegel, Briegel, Briegel, Danielson, Donato, Eidelman, Endo, Haimoto, Herrmann, Hollenberg, Hund, Hund, Jonsson, Keh, Lindner, Marshall, Metinko, Munck, Mussack, Mussack, Pelinka, Pelinka, Rosen, Schwarz, Stanimirovic, Usui, Vincent, Waage, Weiss, Westaby, Wheeler, Wiesmann, Wunderlich, Young   +46 more
core   +2 more sources

Yi-nao-jie-yu Prescription Exerts a Positive Effect on Neurogenesis by Regulating Notch Signals in the Hippocampus of Post-stroke Depression Rats

Frontiers in Psychiatry, 2018
Post-stroke depression (PSD) is one of the most frequent complications of stroke. The Yi-nao-jie-yu prescription (YNJYP) is an herbal prescription widely used as a therapeutic agent against PSD in traditional Chinese medicine.
Huiling Tian, Xiaoli Li, Qisheng Tang, Wen Zhang, Qingmeng Li, Xinyue Sun, Ruizhen Zhao, Chongyang Ma, Haipeng Liu, Yushan Gao, Fei Han   +10 more
doaj   +1 more source

Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience. [PDF]

, 2017
AimTo study differences of presentation, management, and prognosis of alcoholic hepatitis in Latinos compared to Caucasians.MethodsWe retrospectively screened 876 charts of Caucasian and Latino patients who were evaluated at University of California ...
Durbin-Johnson, Blythe, Halsted, Charles H, Medici, Valentina, Pinon-Gutierrez, Rogelio   +3 more
core   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources