Results 11 to 20 of about 173,009 (218)

Monoclonal Antibody Therapy in Neuromyelitis Optica Spectrum Disorders: a Meta-analysis of Randomized Control Trials

Frontiers in Pharmacology, 2021
Background: To update the efficacy and safety data of monoclonal antibodies for the treatment of neuromyelitis optica spectrum disorders (NMOSD) and explore the differences in the effect of treatment between patients seropositive and seronegative for ...
Fanxin Kong, Fanxin Kong, Jianjun Wang, Jianjun Wang, Haotao Zheng, Haotao Zheng, Haobin Cai, Haobin Cai, Jun Hua, Jun Hua, Liling Li, Liling Li   +11 more
doaj   +1 more source

Bilateral corpus callosum and corona radiata infarction due to cerebral venous sinus thrombosis presenting as headache and acute reversible aphasia: a rare case report

BMC Neurology, 2020
Background Cerebral venous sinus thrombosis (CVST), a rare cause of cerebral infarction, is often unrecognized at initial presentation. We report the case of a patient with bilateral corpus callosum and corona radiata infarction due to cerebral venous ...
Rui Lan, Yun-zhi Ma, Xiao-ming Shen, Ji-tao Wu, Chun-qing Gu, Yong Zhang   +5 more
doaj   +1 more source

Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine

Medicine, 2022
. Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
doaj   +1 more source

Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

BMC Neuroscience, 2021
Background It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS patients remains unclear. We aimed to
Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang, Fangyue Zeng, Hao Huang, Chunyuan Zhang, Zhiliang Guo   +9 more
doaj   +1 more source

Clinical safety and possible efficacy of tirofiban in combination with intravenous thrombolysis by recombinant tissue plasminogen activator for early treatment of capsular warning syndrome (CWS)

Frontiers in Neuroscience, 2022
The purpose of this study was to assess the efficacy and safety of the combination of tirofiban with intravenous thrombolysis (IVT) in treating patients with capsular warning syndrome (CWS) who failed to respond to the treatment of intravenous ...
Yunzhu Liu, Shiyong Li, Dongdong Hao, Zhongping Zhang, Yongxin Yi, Jiayang Fang, Weizhi Lin, Min Zhang   +7 more
doaj   +1 more source

Multiple intracranial enlarging dissecting aneurysms: a case report

BMC Neurology, 2023
Background Cases of multiple cerebral aneurysms are rare. In this case report, we describe a male patient with multiple, enlarging, and ruptured aneurysms. The two aneurysms were believed to be dissecting aneurysms.
Yingbin Li, Xiaoxin Bai, Huai Tu, Zhimin Zou, Yan Huang, Jun Cai   +5 more
doaj   +1 more source

Percutaneous transluminal angioplasty and stenting vs aggressive medical management on stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis

Scientific Reports, 2023
There are currently two main treatment strategies mainly for high-risk patients: percutaneous transluminal angioplasty and stenting (PTAS) and aggressive medical management (AMM). However, the choice between PTAS or AMM remains controversial for patients
Zhiyu Lai, Mingqiang Peng, Haoming He, Yingbin Li, Xiaoxin Bai, Jun Cai   +5 more
doaj   +1 more source

Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells

Journal of Integrative Neuroscience, 2023
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative brain disorder currently without satisfactory therapeutic treatments. Triggering receptors expressed on a myeloid cells-2 (Trem2) gene mutation has been reported as a powerful AD risk ...
Gongcan Chen, Mengmeng Han, Yi Chen, Yaling Lei, Min Li, Li Wang, Chen Wang, Yangxue Hu, Jinghu Niu, Cong Yang, Yousheng Mo, Qi Wang, Lin Yang, Xiang Chang   +13 more
doaj   +1 more source

Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells

Analytical Cellular Pathology, 2021
Oxidative stress-induced neuronal damage is a main cause of ischemia/reperfusion injury. Curcumin (Cur), the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric), exhibits excellent antioxidant effects. Previous studies have
Teng Zhang, Xiaomin Chen, Yueqing Qu, Yanbing Ding   +3 more
doaj   +1 more source

Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Frontiers in Endocrinology, 2022
Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact ...
Tingting Wang, Limin Wu, Qiuying Chen, Kuiyu Chen, Fang Tan, Jiabo Liu, Xiang Liu, Hui Han   +7 more
doaj   +1 more source