Results 31 to 40 of about 235,104 (268)

Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease

Scientific Reports, 2023
Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear.
Dan Wang, Daojun Xie, Juan Zhang, Biao Cai, Bo Yang, Lei Zhou, Xiaofeng Huang   +6 more
doaj   +1 more source

Ammonia, infection and inflammation in hepatic encephalopathy. [PDF]

, 2007
For over a century, we have known that ammonia is important in the pathogenesis of hepatic encephalopathy. Studies in patients with acute liver failure have shown rapid progression to severe encephalopathy in those patients with evidence of a systemic ...
Shawcross, D.L., Shawcross, Deborah Lindsay   +1 more
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Antidepressant-Like Effect of Geniposide in Mice Exposed to a Chronic Mild Stress Involves the microRNA-298-5p-Mediated Nox1

Frontiers in Molecular Neuroscience, 2021
Depression is a common mental disorder that presents a considerable challenge for public health. The natural product geniposide has neuroprotective effects on depression, but the underlying mechanism behind these effects had remained undefined.
Tianyu Zou, Jielin Zhang, Yongxiu Liu, Yiming Zhang, Kazuo Sugimoto, Cheng Mei   +5 more
doaj   +1 more source

Nutrition and Hepatic Encephalopathy

, 2012
This Chapter evaluates the correlation between malnutrition and hepatic encephalopathy in liver ...
MERLI, Manuela, RIGGIO, Oliviero, Michela Giusto, Manuela Merli, GIUSTO, MICHELA, Oliviero Riggio   +5 more
core   +1 more source

No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older [PDF]

, 2010
Background The bovine spongiform encephalopathy (BSE) epidemic presented homogeneity of the phenotype. This classical BSE (called C-type) was probably due to the contamination of the food chain by a single prion strain.
Caroline Rodeghiero, S. Durand, Alexandre Dobly, Roels, S., Emmanuel Vanopdenbosch, A. Dobly, Sloovere, J., de, Jessica De Sloovere, Patrick Van Muylem, Keulen, L.J.M., van, Stefan Roels, Vanopdenbosch, E., J. De Sloovere, Dobly, A., Langeveld, J.P.M., Lucien van Keulen, P. Van Muylem, Muylem, P., van, Jan Langeveld, Rodeghiero, C., Stéphanie Durand, L. van Keulen, Geeroms, R., C. Rodeghiero, R. Geeroms, Durand, S.V.M., J. Langeveld, S. Roels, E. Vanopdenbosch, Riet Geeroms   +29 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway

Stem Cells International
Recently, there has been a surge of interest in enhancing the differentiation of neural stem cells (NSCs) and supplementing dopamine neurons as a potential treatment for Parkinson’s disease, the second most prevalent neurodegenerative disorder.
Zicong Wu, Jianing Zhang, Han Gao, Wentao Li   +3 more
doaj   +1 more source

The Peripheral Benzodiazepine Receptor and Neurosteroids in Hepatic Encephalopathy

, 1997
Hepatic encephalopathy (HE) represents one of the most common events in terminal liver failure. Acute HE (fulminant hepatic failure, FHF) presents with the abrupt onset of delirium, seizures, and coma, and has a mortality rate of about 90%. The principal
Norenberg, Michael D, Itzhak, Yossef, Bender, Alex S, Yossef Itzhak, Alex S. Bender, Michael D. Norenberg   +5 more
core   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source