Results 101 to 110 of about 145,080 (300)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Interferometrische Encoder zu lineare Verschiebungsmetrologie [PDF]
, 2013 Currently one of the most challenging demands on linear displacement metrology comes from positioning of the wafer stages of the lithography machine tools, which requires measurement ranges of hundreds of millimeters and measurement uncertainties of ...
Guan, Jun
core +1 more source
Transformers in multivariate time series forecasting: a review [PDF]
ریاضی و جامعهLong-term forecasting of multivariate time series is a fundamental challenge in the field of machine learning, with critical applications in numerous domains such as energy, transportation, and financial markets.
Esmaeil Chitgar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Contrastive Learning Augmented Graph Auto-Encoder
Graph embedding aims to embed the information of graph data into low-dimensional representation space. Prior methods generally suffer from an imbalance of preserving structural information and node features due to their pre-defined inductive biases ...
Yafei Liu (1590211) +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
UniX-Encoder: A Universal $X$-Channel Speech Encoder for Ad-Hoc Microphone Array Speech Processing [PDF]
, 2023 The speech field is evolving to solve more challenging scenarios, such as multi-channel recordings with multiple simultaneous talkers. Given the many types of microphone setups out there, we present the UniX-Encoder. It's a universal encoder designed for
Shao, Yiwen +3 more
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