Results 151 to 160 of about 3,692,662 (365)

Uniform data encodings

open access: yesTheoretical Computer Science, 1980
AbstractGiven two finite, directed, edge-labeled graphs, G (the guest) and H (the host) an encoding of G into H is an injection of guest-graph edges into host-graph paths that induces an injection of G vertices into H vertices. An encoding is uniform if like-labeled edges map to like-labeled paths.
Lawrence Snyder   +2 more
openaire   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

The Impact of Focusing on Different Features During Encoding on Young and Older Adults’ Source Memory

open access: yesOpen Psychology, 2019
Age-related source memory deficits result, in part, because young and older adults attend to different information. We asked whether focusing young and older adults‘ attention on specific features at encoding would result in similar subjective ...
Mitchell Karen J., Hill Erin M.
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Interopérabilité des bases de données scientifiques : une sobriété de façade

open access: yesHumanités Numériques
Any task is more sustainable if it consumes fewer resources, over its entire lifecycle. Some of the challenges of Digital Humanities are tasks related to interoperability between databases, such as documentation, alignment, migration and publication ...
Régis Witz, Guillaume Porte
doaj   +1 more source

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