Results 201 to 210 of about 2,462,637 (289)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates. [PDF]

Curr Biol
Mildren RL, Gómez LJ, Cullen KE.
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Evidence for strong purifying selection of human <i>47S</i> ribosomal RNA genes. [PDF]

Proc Natl Acad Sci U S A
Ma X, Chow F, Galbraith B, Sultanov D, Behar EK, Hochwagen A.   +5 more
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Dysfunction of the episodic memory network in the Alzheimer's disease cascade. [PDF]

Nat Commun
Lattmann R, Vockert N, Bernal J, Wesenberg J, Suksangkharn Y, Yakupov R, Schütze H, Glanz W, Incesoy E, Butryn M, Lüsebrink F, Schmid M, Stark M, Kleineidam L, Spottke A, Coenjaerts M, Brosseron F, Fliessbach K, Schneider A, Dechent P, Scheffler K, Hetzer S, Ramirez A, Laske C, Sodenkamp S, Altenstein S, Schneider LS, Gref D, Spruth EJ, Lohse A, Schott BH, Wiltfang J, Kilimann I, Goerss D, Rostamzadeh A, Priller J, Peters O, Hellmann-Regen J, Teipel S, Wagner M, Jessen F, Maass A, Ziegler G, Düzel E.   +43 more
europepmc   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

A High-Speed Visual BCI Based on Hybrid Frequency-Phase-Space Encoding and High-Density EEG Decoding. [PDF]

Cyborg Bionic Syst
Ming G, Pei W, Tian S, Chen X, Gao X, Wang Y.   +5 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Analysis of the virulence potential, ability to form biofilms and susceptibility to bacteriocins of <i>Staphylococcus aureus</i> strains isolated from livestock and wildlife. [PDF]

J Vet Res
Trościańczyk A, Nowakiewicz A, Lauková A, Osińska M, Hahaj-Siembida A.   +4 more
europepmc   +1 more source