Results 171 to 180 of about 221,241 (267)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The effect of wildfire air pollution on local hospital admissions in New York. [PDF]

Environ Res Commun
Yazdi MD, Sasaki N, Qiu M, Huang G, Sheffield PE.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance. [PDF]

Crit Care Explor
Shinnick FJ, Hasson DC, Kothari U, Shah A, Odum JD, Braun CG, Dixon CG, Fitzgerald JC, Martin SD, Terry N, Dziorny AC, Evidence-Driven Evaluation and Management of fluid Accumulation (EDEMA) Collaborative.   +11 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design.

JAMA Netw Open
Wiegand RE, Chickery S, Yang DH, Ball SW, DeSilva MB, Dascomb K, Irving SA, Natarajan K, Klein NP, Grannis SJ, Ong TC, Rowley EAK, Yates A, Zhuang Y, Wilson S, McEvoy CE, Essien IJ, Akinsete OO, Naleway AL, Koppolu P, Zerbo O, Hansen JR, Jacobson KB, Block L, Dixon BE, Duszynski T, Rogerson C, Barron MA, Chavez C, Mak J, Ciesla AA, Godfrey M, Kautz A, Najdowski M, Link-Gelles R, DeCuir J, Payne AB.   +36 more
europepmc   +1 more source

Immigration enforcement in hospitals: a framework for health systems. [PDF]

Trauma Surg Acute Care Open
Sakran JV, McDonough K, Arciaga Z, Joseph B.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Implementation of a Standardized Management Algorithm for Cannabis Hyperemesis Syndrome in a Pediatric Emergency Department. [PDF]

Pediatr Emerg Care
Kelly CM, Attridge M, Katsogridakis YL, Mrozek L, Jackson K, Hoffmann JA.   +5 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source