Results 191 to 200 of about 441,703 (265)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Real-World Bleeding Outcomes Among Hospitalized Patients Receiving Apixaban or Rivaroxaban: A Single-Center Retrospective Cohort Study. [PDF]

Pharmaceuticals (Basel)
O'Rear C, Chapa-Rodriguez A, Singh A, Afzal S, Acharya R, Wickham M, Younus U.   +6 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Impact of Transitioning From Application-Specific to Global Point-of-Care Ultrasound Privileging on Utilization and Emergency Department Length of Stay. [PDF]

Acad Emerg Med
Boivin Z, Sangal RB, Rothenberg C, Venkatesh AK, Moore CL, Liu RB.   +5 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Prescription Analysis in the Digital Era: Comparing Artificial Intelligence-Based Versus Manual Approaches. [PDF]

Cureus
Kakasaniya G, Mer RJ, Mehta DS, Chhaiya S, Acharya T, Trivedi M, Sanghvi M, Zatiya A, Ved J, Patel M.   +9 more
europepmc   +1 more source

The Effects of Outreach Initiatives on Equitable Access to Dermatology Services: Single-Center Retrospective Analysis. [PDF]

JMIR Dermatol
Albrecht JM, Lyon JD, Birdsall M, Broadbent E, Ufkes N, Zone S, Bowen A, Hull C, Madigan L, Snyder AM, Wu C, Lewis BK.   +11 more
europepmc   +1 more source