Results 111 to 120 of about 459,845 (362)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

EAEBHCM:an extended attribute encryption based hidden credentials model

Tongxin xuebao, 2012
The identity-based encryption based hidden credentials has three problems that it can not supports 1-N communication,endures no identity fuzzy and lefts open to conspiracy crack.An extended attribute encryption based hidden credentials model(EAEBHCM) was
Wei-jin GE, Xiao-hui HU
doaj  

ReACT_OCRS: An AI-Driven Anonymous Online Reporting System Using Synergized Reasoning and Acting in Language Models

IEEE Access
Victims and witnesses of cybercrime often hesitate to report incidents due to concerns over privacy, complexity, and fear of retaliation. Traditional reporting mechanisms require manual data entry, creating accessibility barriers and delaying response ...
Amir Aboubakr Shaker Mahmoud, Wesam Shishah, Nilay R. Mistry   +2 more
doaj   +1 more source

A simple encryption algorithm [PDF]

, 2017
In this paper I present a Simple Encryption Algorithm (SEAL), by which 128-bit long blocks can be quickly encrypted/decrypted. The algorithm is designed to run efficiently in software without any specialized hardware while still guaranteeing a strong degree of confidentiality.
openaire   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Implementation of shared file encrypted storage hierarchical access control scheme

网络与信息安全学报, 2016
The traditional file sharing way is single,lack of security,and the shared file's permission autonomous control is too high.To solve these problems,a file encrypted storage and hierarchical access control scheme was proposed.Through increasing ...
Li LI, Guo-zhen SHI, Xuan WANG, Yun-fei CI   +3 more
doaj  

Small Pseudo-Random Families of Matrices: Derandomizing Approximate Quantum Encryption

, 2004
A quantum encryption scheme (also called private quantum channel, or state randomization protocol) is a one-time pad for quantum messages. If two parties share a classical random string, one of them can transmit a quantum state to the other so that an ...
Ambainis, Andris, Smith, Adam
core   +2 more sources