Results 41 to 50 of about 88,610 (249)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Artificial intelligence in data storage systems

Advanced Engineering Research, 2020
Introduction. The artificial intelligence (AI) performance in data storage systems is considered. When working with data, the advantage of its use both in economic terms and for security is determined. The work objective is the introduction of artificial
V. V. Zhilin, O. A. Safar'yan
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Secure Fully Homomorphic Authenticated Encryption

IEEE Access, 2021
Homomorphic authenticated encryption allows implicit computation on plaintexts using corresponding ciphertexts without losing privacy, and provides authenticity of the computation and the resultant plaintext of the computation when performing a ...
Jeongsu Kim, Aaram Yun
doaj   +1 more source

Privacy-Preserving Searchable Encryption Scheme Based on Public and Private Blockchains [PDF]

, 2022
Ruizhong Du, Caixia Ma, Mingyue Li
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Reversible AMBTC-Based Data Hiding With Security Improvement by Chaotic Encryption

IEEE Access, 2019
Social networking and cloud computing are being extensively used, and in this era, the frequency of sending information or images to each other is increasing. The prevention of private information leakage during communication over the Internet has become
Hsiang-Ying Wang, Hsin-Ju Lin, Xiang-Yun Gao, Wen-Huang Cheng, Yung-Yao Chen   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Implementasi Algoritma Kriptografi RSA untuk Enkripsi dan Dekripsi Email

Jurnal Teknologi dan Sistem Komputer, 2015
In the world of Internet nothing is really safe. There's always a gap in any application made. Likewise in email delivery. To minimize attacks on the data transmission is usually applied cryptography.
Albert Ginting, R. Rizal Isnanto, Ike Pertiwi Windasari   +2 more
doaj   +1 more source