Results 171 to 180 of about 253,555 (314)

Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of childhood asthma and obesity. [PDF]

Transl Pediatr
Gou H, Zhou H, Zhao M, Zhang X, Zhao Q.
europepmc   +1 more source

The New Encyclopedia Britannica [28]

, 1995
Encyclopedia Britannica, Inc
core  

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Exploring the mechanisms of Cangfu Daotan decoction in homotherapy for heteropathy of polycystic ovary syndrome, insulin resistance, infertility, and obesity. [PDF]

Medicine (Baltimore)
Chen H, Deng L, Chen H, Cai B.
europepmc   +1 more source

The New Encyclopedia Britannica [24]

, 1995
Encyclopedia Britannica, Inc
core  

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Study on the mechanism of action of Chaihu Guizhi Ganjiang Decoction for the treatment of slow transit constipation combined with depression based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Zhao Z, Zhu C, Meng L, Zhang S.
europepmc   +1 more source

The New Encyclopedia Britannica [1]

, 1995
Encyclopedia Britannica, Inc
core  

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Characterization of the plasma metabolomic profile in infantile epileptic spasms syndrome. [PDF]

Transl Pediatr
Jiang L, Zhu M, Zhang Y, Yuan Z, Gao F.
europepmc   +1 more source