Results 71 to 80 of about 6,182 (303)
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
SEMANTIC AND THEMATIC NAVIGATION IN ELECTRONIC ENCYCLOPEDIAS
, 1999 In the field of electronic publishing, encyclopedias represent a unique sort of text for investigating advanced methods of navigation. The user of an electronic encyclopedia normally expects special methods for accessing the entries in an encyclopedia ...
A.Witt Henni Lobin +1 more
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Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
, 2016 Since the inception of printing in Europe in the fifteenth century, encyclopedias have become popular and widespread all over the continent. During the eighteenth century, dictionaries and other knowledge-communicating books constituted a major part of ...
Schneider, Ulrich Johannes
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, 2021 In Stranded Encyclopedias, 1700–2000: Exploring Unfinished, Unpublished, Unsuccessful Encyclopedic Projects, fourteen scholars turn to the archives to challenge the way the history of modern encyclopedism has long been told.
Simonsen, Maria, +2 more
core +1 more source
Енциклопедичний Вісник України, 2018 The research is devoted to issues of the ecosystem of encyclopedic knowledge. The fact is that a reference information is now increasingly used as means of media manipulation in level of public consciousness (for political, ideological, and economic ...
Oleksandr Ishchenko
doaj +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Encyclopedia industry under fire: reflections upon the monograph “Ukrainian encyclopedias in current socio-communicative challenges” (Kyiv, 2024) [PDF]
Енциклопедичний Вісник УкраїниThe Ukraine’s encyclopedia industry has faced several new challenges as a result of the current war, including funding issues, personnel shortages, and limited access to verified information sources.
Sergii Bortnyk, Sergii Segeda
doaj +1 more source