Results 91 to 100 of about 6,182 (303)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
China’s digital nationalism: search engines and online encyclopedias
, 2020 Search engines play a vital role in positioning, organizing, and disseminating knowledge in China. Although there is a growing interest in China’s search engines, relatively few researches systematically examine their role involving nationalism. In order
Zhang, D.
core +1 more source
Advanced Science, EarlyView.This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu +9 more
wiley +1 more source
Specifics of Electronic Encyclopedias Compared to “Printed” Book-Format Encyclopedias [PDF]
В статье проводится сравнительный анализ электронных и печатных энциклопедий, раскрывая их эволюцию от античных компендиумов до современных цифровых платформ.
Koptseva, Maria S. +3 more
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Advanced Science, EarlyView.FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong +10 more
wiley +1 more source
Open Source Software for Open Access Encyclopedias [PDF]
, 2017 The main objective of the project “Open Encyclopedia System (OES)” is to develop a standardized web-based open source platform for building and maintaining scientific online encyclopedias, which will be publicly available, free of charge on the ...
Egilmez, Ilker +2 more
core +1 more source
Advanced Science, EarlyView.This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou +12 more
wiley +1 more source
Encyclopedia of Poetics and Poetics of Encyclopedias
, 2012 History of poetics is also the history of handbooks, vocabularies and encyclopedias in which are the main terms and categories of poetics explained. Every handbooks as well have a special own and unmistakable poetics.
Sládek, Ondřej
core
Енциклопедичний Вісник України, 2019 The article is dedicated to Taras Pustovit who is an encyclopedia scholar, archivist, local historian, public figure. This year, Taras Pustovit is celebrating his 60th anniversary. The main ways of his life are considered, achievements in local history,
Maryna Fedorova
doaj +1 more source