Results 91 to 100 of about 4,081,530 (304)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Correction: Palliative care symptoms, concerns and well-being of older people with frailty and complex care needs upon hospital discharge: a cross-sectional study

BMC Palliative Care, 2022
Kim de Nooijer, Nele Van Den Noortgate, Peter Pype, Lieve Van den Block, Lara Pivodic   +4 more
doaj   +1 more source

A post-mortem population survey on foetal-infantile end-of-life decisions: a research protocol

BMC Pediatrics, 2018
Background The death of a child before or shortly after birth is frequently preceded by an end-of-life decision (ELD). Population-based studies of incidence and characteristics of ELDs in neonates and infants are rare, and those in the foetal-infantile ...
Laure Dombrecht, Kim Beernaert, Ellen Roets, Kenneth Chambaere, Filip Cools, Linde Goossens, Gunnar Naulaers, Luc De Catte, Joachim Cohen, Luc Deliens, on behalf of the NICU consortium   +10 more
doaj   +1 more source

End of Life Care: Achieving Quality in Hostels and for Homeless People, A Route to Success [PDF]

, 2010
This publication aims to provide a practical guide to support hostel staff in ensuring that people nearing the end of their life receive high quality end of life ...

core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The central role of housing key workers in supporting healthcare interactions for people experiencing homelessness and implications for palliative care: a qualitative study

BMC Palliative Care
Background People experiencing homelessness access specialist palliative care late in their illness trajectory, if at all. There is also little evidence they receive generalist palliative care or are given opportunities to engage in Advance Care Planning.
Merryn Gott, Lisa Williams, Janine Wiles, Stella Black, Tess Moeke-Maxwell, Jackie Robinson, Te Ārai Palliative Care and End of Life Research Group   +6 more
doaj   +1 more source

Improving support for older people looking after someone with advanced cancer [PDF]

, 2011
The briefing paper is about the findings and recommendations from a research project conducted at the University of Nottingham, with funding awarded by Macmillan Cancer Support.
Bird, Lydia, Kennedy, Sheila, Seymour, Jane, et al   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transitions at the end of life for older adults - patient, carer and professional perspectives [PDF]

, 2014
BackgroundThe end of life may be a time of high service utilisation for older adults. Transitions between care settings occur frequently, but may produce little improvement in symptom control or quality of life for patients.
, , , , , , , , , Abarshi, Addington-Hall, Ahearn, Ashton, Barker, Boling, Breyer, Busse, Cameron, Coleman, Coleman, Coleman, Coleman, Craig, Dixon, Dobrzanska, Donabedian, Ellershaw, Feinstein, Fleming, Freeman, Freeman, Fries, Fries, Glasby, Goldacre, Golden, Gott, Gravelle, Gwadry-Sridhar, Hanratty, Hanratty, Hanratty, Hanratty, Harrison, Henderson, Himsworth, Hogan, Hubbard, Hudson, Ingleton, Jencks, Jovicic, Kane, Klinkenberg, Kydd, Levine, Linertova, Lowson, Luhrs, McPherson, Mor, Moran-Ellis, Moss, Moss, Mur-Veeman, Murray, Murray, Murray, Murtaugh, Naylor, O’Cathain, Parker, Partridge, Pring, Quinn, Rich, Rich, Roos, Ross, Ruth, Saliba, Seshamani, Seshamani, Seymour, Shaw, Shepperd, Spencer, Swinkels, Szczepura, Tahan, Terrell, Trask, Twigg, Twigg, Van den Block, Werblow, Zweifel   +96 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source