Results 71 to 80 of about 175,061,202 (302)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Beliefs, death, anxiety, denial, and treatment preferences in end-of-life care: a comparison of social work students, community residents, and medical students.

, 2005
This study examined cultural and religious beliefs, death anxiety, denial, and medical treatment preferences in end-of-life care in a sample of social work students, community residents, and medical students in a mid-western city of 49,000.
Chan, CL, Perry, DC, Reese, DJ, Schlinger, JM, Wiersgalla, D   +4 more
core   +1 more source

Limiting futile therapy as part of end-of-life care in intensive care units

, 2022
The debate about medical futility often involves intensive care units where life-support procedures are routinely applied. Futile therapy is part of end-of-life therapy. In the discussion about medical futility it is important to distinguish the effect
Maksymilian Gajda, Ewa Kucewicz-Czech, Małgorzata Kowalska, Maria Damps, Ludwik Stołtny   +4 more
core   +1 more source

Uncovering the end-of-life trajectories of older people with serious chronic illnesses: study protocol for the quantitative longitudinal study of the TRAJECT project

BMJ Open
Introduction Older people who die with a serious chronic disease are at risk of experiencing extended periods (ie, months or years) of fluctuations and deterioration in their health and well-being.
Lieve Van den Block, Aline De Vleminck, Lara Pivodic, Nele Van Den Noortgate, Eline Naert, Lore Decoster, Casper Van den Bossche, Khyati Tripathi   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Social workers’ involvement in advance care planning: a systematic narrative review

BMC Palliative Care, 2017
Background Advance care planning is a process of discussion that enables competent adults to express their wishes about end-of-life care through periods of decisional incapacity.
Chong-Wen Wang, Cecilia L. W. Chan, Amy Y. M. Chow   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The end-of-life care practices of emergency care nurses and the factors that influence these practices: An integrative review

, 2022
Introduction: Due to philosophical tensions between end-of-life care and emergency care, nurses in the emergency department face challenges in the provision of end-of-life care. The purpose of this integrative review was to synthesise evidence of the end-
Aquino, Jose, Crilly, Julia, Ranse, Kristen, https://orcid.org/, Kristen Ranse, Julia Crilly, Jose Aquino   +6 more
core   +1 more source

End-of-Life Care in Canada

Clinical and Investigative Medicine, 2013
End-of-life care and planning is critically important to the next decades of health care in Canada. In our country, between 2005 and 2036, the number of seniors 65 years and older is projected to increase by up to 25%, and the number of deaths by 65%.
Robert, Fowler, Michael, Hammer
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source