Results 91 to 100 of about 175,061,202 (302)

Quality care at the end of life

BMJ, 2002
2 pages. ; Editorial advocating improved end-of-life care.
Singer, Peter, Bowman, Kerry
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change

BMC Geriatrics, 2018
Background Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings.
J. Gilissen, L. Pivodic, C. Gastmans, R. Vander Stichele, L. Deliens, E. Breuer, L. Van den Block   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Correction: Palliative care symptoms, concerns and well-being of older people with frailty and complex care needs upon hospital discharge: a cross-sectional study

BMC Palliative Care, 2022
Kim de Nooijer, Nele Van Den Noortgate, Peter Pype, Lieve Van den Block, Lara Pivodic   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Inclusiveness in research teams: reflections on the Te Ārai Palliative Care and End of Life Research Group, a decade on

Improving palliative care and responding to inequities experienced by underserved communities and people require greater diversity within research teams to accommodate different life histories, experiences, and cultural needs.
Gott, Merryn, Smith, Brianna, Moeke-Maxwell, Tess   +2 more
core   +1 more source

Living Memory Home for Dementia Care Pairs (LMH-4-DCP): study protocol for a pilot randomized trial of a web-based reminiscence intervention for family caregivers and persons with dementia

Pilot and Feasibility Studies
Background Family caregivers provide most of the emotional, physical, and logistical support for people living with Alzheimer’s disease and related dementias (ADRD).
Francesca B. Falzarano, Annabelle Greenfield, Sydney C. Saviano, Sindhu Kolla, Sosi Korian, Francesco Osso, Joseph Miller, Paul K. Maciejewski, Heather E. Whitson, Holly G. Prigerson   +9 more
doaj   +1 more source

Differences in place of death between lung cancer and COPD patients: a 14-country study using death certificate data

npj Primary Care Respiratory Medicine, 2017
Lung disease: improving end-of-life care Structured palliative care similar to that offered to cancer sufferers should be in place for patients with chronic lung disease. Joachim Cohen at Vrije University in Brussels and co-workers examined international
Joachim Cohen, Kim Beernaert, Lieve Van den Block, Lucas Morin, Katherine Hunt, Guido Miccinesi, Marylou Cardenas-Turanzas, Bregje Onwuteaka-Philipsen, Rod MacLeod, Miguel Ruiz-Ramos, Donna M Wilson, Martin Loucka, Agnes Csikos, Yong-Joo Rhee, Joan Teno, Winne Ko, Luc Deliens, Dirk Houttekier   +17 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source