Results 101 to 110 of about 4,081,530 (304)

Being present: oncologists' role in promoting advanced cancer patients' illness understanding

Cancer Medicine, 2018
Realistic illness understanding is essential to an advanced cancer patient's ability to make informed medical decisions at the end of life. This study sought to determine whether advanced cancer patients better understood the late stage of their cancer ...
Simon M. Cohen, Renee C. Maciejewski, Manish A. Shah, Kelly M. Trevino, Megan J. Shen, Paul K. Maciejewski, Holly G. Prigerson   +6 more
doaj   +1 more source

Enhancing integrated palliative care: what models are appropriate? A cross-case analysis

BMC Palliative Care, 2017
Background Effective integration between hospices, palliative care services and other local health care services to support patients with palliative care needs is an important international priority.
Sheila Payne, Rachael Eastham, Sean Hughes, Sandra Varey, Jeroen Hasselaar, Nancy Preston   +5 more
doaj   +1 more source

Learning from PPO Investigations: End-of-Life Care [PDF]

, 2013
With a large and ageing prison population, the Prison Service has to deal with more foreseeable deaths from terminal and incurable illnesses than ever before. This brings new challenges for both prison regimes and prison facilities to accommodate the end

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Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Deep Ecology and End-of-Life Care

, 2009
Physicians and nurses caring for terminally ill patients are expected to center their moral concerns almost exclusively on the needs and welfare of the dying patient and the patients family.
Carrick, Paul
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Spiritual care at the end of life: whose job is it? [PDF]

, 2010
Interest in and recognition of the function of religious and spiritual coping in adjustment to serious illness has been growing. In particular, there has been increasing interest in the importance of understanding and valuing patients' individual ...
Psaila, Claudia, Watts, Jacqueline H.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Investigating experiences of people with advanced breast or lung cancer in their natural context: protocol for an experience sampling study

BMJ Open
Introduction People with advanced cancer can experience a wide range of multidimensional symptoms or concerns, but little is known about when and how these fluctuate in daily life.
Lieve Van den Block, Kim de Nooijer, Lara Pivodic, Geert Crombez, Eline Naert, Joran Geeraerts, Mark De Ridder   +6 more
doaj   +1 more source

The Quality of Death: Ranking End-of-Life Care Across the World [PDF]

, 2010
As the proportion of the world's population grows disproportionately older, the need for end-of-life services will only increase. This paper ranks 40 countries in terms of the quality and availability of end-of-life care.
Sarah Murray
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