Results 151 to 160 of about 175,061,202 (302)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Quality Indicators in End-of-Life Care for Children With Cancer in Low- and Middle-Income Countries. [PDF]

Cancer Med
McNeil MJ, Quintero XG, Salek M, Agulnik A, Downing J, Dussel V, Friedrich P, Garcia WG, Johnston EE, Movsisyan N, Namisango E, Rao K, Sansom-Daly UM, Widger K, Wiener L, Rodriguez-Galindo C, Baker JN.   +16 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

End of Life at Home: Co-Creating an Ecology of Care

, 2015
The majority of people (70–80%) when asked where they would prefer to die say they want to die in the comfort and intimacy of their own homes (Gomes et al., 2013; Palliative Care Australia, 2011). However, only 16–20% of people manage to fulfil this wish.
Leonard, Rosemary (R8047), Noonan, Kerrie (S30020), Yardley, Ainslie (R12257), Rosenberg, John P., Horsfall, Debbie (R7851)   +4 more
core  

Paramedics' Perceptions and Experiences Providing End-of-Life Care: A Cross-Sectional Survey. [PDF]

Healthcare (Basel)
Hasson F, Campling N, Keeney S, Slater P, McIlfatrick S, Wolfe J.   +5 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Electronic health record data to develop indicators of end-of-life care quality. [PDF]

BMJ Support Palliat Care
Bagri S, Julian S, Davies M, Scobie S, Schaffer AL, OpenSAFELY Collaborative.   +5 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Culturally Sensitive End-of-Life Care for Persons With Dementia: A Global Scoping Review and Conceptual Framework. [PDF]

J Transcult Nurs
Wang WG, Li C, Murali KP.
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source