Results 81 to 90 of about 11,268,090 (297)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cardiovascular Disease Assessment Prior to Kidney Transplantation

Methodist DeBakey Cardiovascular Journal, 2022
Cardiovascular disease is highly prevalent and the leading cause of mortality in patients with chronic kidney disease, end-stage kidney disease, and kidney transplantation.
Angelina R. Edwards, Elise C. Ewing
doaj   +1 more source

Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease

Nature Medicine, 2019
Chronic kidney disease is common in the general population and associated with excess cardiovascular disease (CVD), but kidney function does not feature in current CVD risk-prediction models.
J. Lees, Claire E. Welsh, C. Celis-Morales, D. Mackay, J. Lewsey, S. Gray, D. Lyall, J. Cleland, J. Gill, P. Jhund, J. Pell, N. Sattar, P. Welsh, P. Mark   +13 more
semanticscholar   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD [PDF]

, 2011
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide ...
Kronenberg, F, Fox, Caroline S., Hoffmann, M.M., Powe, Neil, Hwang, Shih-Jen, Siscovick, D.S. (David), W H Kao, Paulweber, Bernhard, Hwang, SJ, Ravi I Thadhani, Rivadeneira Ramirez, F. (Fernando), Carsten A., Böger, Hoffmann, MM, Huang, C., O'Seaghdha, C.M., Kutalik, Z, Köttgen, A., Hoffmann, Michael M., Coassin, S, Heid, Iris M., Hoffmann, Michael M, H.-Erich Wichmann, Witteman, J., Yang, Q. (Qiong Fang), Powe, N., Jacques S Beckmann, Witteman, Jacqueline, Shlipak, M.G. (Michael), Huang, CM, Rettig, Rainer, null null, Heid, I.M. (Iris), Barbara Kollerits, Haun, M., Coassin, S. (Stefan), Krane, V. (Vera), Teumer, A. (Alexander), Hofman, Bert, Powe, N. (Neil), Haun, M, Kronenberg, F. (Florian), Bochud, Murielle, Kutalik, Zoltan, Haak, Thomas, Wichmann, H.E., Kao, W.H.L. (Wen), Wichmann, H.E. (Heinz Erich), Haak, T., Heid, I.M., Siscovick, D, Kronenberg, Florian, Wanner, C, Bochud, M., Krämer, B.K., Hofman, A., Caroline S. Fox, Bernhard K Krämer, Haun, Margot, Carsten A Böger, Wichmann, H-Erich, Kim, Stuart K., Heid, IM, Wichmann, H.-Erich, Wanner, Christoph, Böger, Carsten A., Gorski, M. (Mathias), Boger, CA, Böger, C.A., Krämer, Bernhard K., Coassin, S., Carsten A. Böger, Fox, C.S., Kollerits, B. (Barbara), Michael M. Hoffmann, Gorski, Mathias, Rivadeneira, Fernando, Heid, Iris M, Li, M., Shlipak, M.G., Coassin, Stefan, Kollerits, Barbara, Haak, T. (Thomas), Kollerits, B, David Siscovick, Man Li, Krämer, Bernhard K, Haak, T, Rettig, R, Thomas Haak, Florian Kronenberg, Coresh, J. (Josef), Abbas Dehghan, Zoltán Kutalik, O'Seaghdha, CM, Li, M, Wichmann, HE, Coresh, Josef, Siscovick, David, O'Seaghdha, Conall M., Hoffmann, M.M. (Michael), Wanner, C., O'Seaghdha, C.M. (Conall), Shlipak, MG, Krane, Vera, Chunmei Huang, Hwang, S.J., Stefan Coassin, Rettig, R. (Rainer), Siscovick, D., Shlipak, Michael G, Teumer, Alexander, Gorski, M., Kronenberg, F., Fox, C.S. (Caroline), Fernando Rivadeneira, Jacqueline Witteman, Huang, Chunmei, Paulweber, B., Thadhani, R.I. (Ravi), W. H. Kao, Neil Powe, Kao, W. H., Shih-Jen Hwang, Uitterlinden, Andre, Conall M O'Seaghdha, Li, M. (Man), Beckmann, J.S. (Jacques), Koettgen, Anna, Paulweber, B, Yang, Qiong, Kottgen, A, Yang, Q, Boes, Eva, Huang, C. (Chunmei), Uitterlinden, André; id_orcid, Köttgen, A. (Anna), Powe, N, Fox, CS, Rivadeneira, F., CKDGen Consortium, Boes, E, Boes, E. (Eva), Yang, Q., Beckmann, Jacques S., Ravi I. Thadhani, Murielle Bochud, Michael M Hoffmann, Conall M. O'Seaghdha, Guo Li, Uitterlinden, A.G. (André), Dehghan, A. (Abbas), Hofman, A. (Albert), Witteman, JCM, Böger, C.A. (Carsten), Albert Hofman, Krämer, B.K. (Bernhard), Iris M Heid, Rettig, R., Michael G Shlipak, Dehghan, Abbas, H-Erich Wichmann, Kao, WH, Kraemer, Bernhard K., Köttgen, Anna, Qiong Yang, Josef Coresh, Bochud, M. (Murielle), Michael G. Shlipak, Dehghan, A., Caroline S Fox, O'Seaghdha, Conall M, Shlipak, Michael G., Teumer, A., Iris M. Heid, Coresh, J, Beckmann, Jacques S, Eva Boes, Bernhard Paulweber, Rainer Rettig, Beckmann, J.S., Kao, W.H., Bochud, M, Teumer, A, Wichmann, Heinz-Erich, Jacques S. Beckmann, Boeger, Carsten A., Haun, M. (Margot), Alexander Teumer, André Uitterlinden, Kollerits, B., Uitterlinden, A., Vera Krane, Krane, V, Anna Köttgen, Kutalik, Z., Bernhard K. Krämer, Kramer, BK, Thadhani, R.I., Krane, V., Margot Haun, Thadhani, Ravi I, Li, Guo, Wanner, C. (Christoph), Paulweber, B. (Bernhard), Böger, Carsten A, Hofman, Albert, Christoph Wanner, Li, Man, Mathias Gorski, Li, G., Witteman, J.C.M. (Jacqueline), Thadhani, RI, Beckmann, JS, Gorski, M, Coresh, J., Kutalik, Z. (Zoltán), Thadhani, Ravi I., Boes, E., Li, G (Guo), Fox, Caroline S, Kao, Wen Hong Linda, CKDGen Consortium, [Study group]   +221 more
core   +2 more sources

Life on the list: an exploratory study of the life world of individuals waiting for a kidney transplant

, 2010
Kidney transplantation is the treatment of choice for many individuals with end stage renal disease (ESRD), as transplantation is reported to offer a greater quality of life than renal dialysis.
Long-Sutehall, Tracy, Frankland, Jane, Addington-Hall, Julia, Sque, Magi, Mason, Juan   +4 more
core   +1 more source

Re: Risk of End-Stage Renal Disease Following Live Kidney Donation

Journal of Urological Surgery, 2014
The authors compare the risk of end-stage renal disease (ESRD) in 96217 kidney donors in the United States, followed for a median of 7.6 years with that of a healthy cohort of 20024 nondonors, followed for a median of 15 years of who are at equally low ...
Muzaale AD, Massie AB, Wang MC, Montgomery RA, McBride MA, Wainright JL, Segev DL   +6 more
doaj  

Shared decision-making and planning end-of-life care for patients with end-stage kidney disease: a protocol for developing and testing a complex intervention

Pilot and Feasibility Studies, 2022
Background Internationally, it has been stressed that advance care planning integrated within kidney services can lead to more patients being involved in decisions for end-of-life care. In Denmark, there is no systematic approach to advance care planning
Louise Engelbrecht Buur, Jeanette Finderup, Henning Søndergaard, Michell Kannegaard, Jens Kristian Madsen, Hilary Louise Bekker   +5 more
doaj   +1 more source

Factors affecting outcomes in patients reaching end-stage kidney disease worldwide: differences in access to renal replacement therapy, modality use, and haemodialysis practices

The Lancet, 2016
More than 2 million people worldwide are being treated for end-stage kidney disease (ESKD). This Series paper provides an overview of incidence, modality use (in-centre haemodialysis, home dialysis, or transplantation), and mortality for patients with ...
B. Robinson, T. Akizawa, K. Jager, P. Kerr, R. Saran, R. Pisoni   +5 more
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source