Results 101 to 110 of about 368,340 (301)

Combined Liver-Kidney Transplantation for Hepatorenal Syndrome

International Journal of Organ Transplantation Medicine, 2015
Among various complications of end-stage liver disease, hepatorenal syndrome has the highest mortality. Patients with both end-stage liver disease and end-stage renal disease are candidates for combined liver-kidney transplantation.
V Kanubhai Sutariya, A Tank, P Ramanlal Modi   +2 more
doaj  

Liver Transplantation for Cholestatic Liver Diseases in Adults

, 2016
Liver transplantation (LT) is an established lifesaving therapy for patients with cholestatic liver diseases, including primary cholestatic diseases, namely primary sclerosing cholangitis and primary biliary cirrhosis, as well as secondary forms of ...
Goldberg, David Seth, Khungar, Vandana
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ADULT LIVER TRANSPLANTATION FOR METABOLIC LIVER DISEASE

, 1998
Inborn errors of metabolism are a recognizable cause of acute or chronic liver disease, as either fulminant hepatic failure, cirrhosis, or hepatocellular carcinoma. Improved survival rates following whole-organ orthotopic liver transplantation (OLT) have
Martin, Paul, Stribling, Rise, Goss, John A   +2 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Survival after liver transplantation in the United Kingdom and Ireland compared with the United States

, 2007
<b>Background and Aim</b>: Surgical mortality in the US is widely perceived to be superior to that in the UK. However, previous comparisons of surgical outcome in the two countries have often failed to take sufficient account of case-mix or ...
van der Meulen, JHP, Copley, LP, van der Meulen, J., Gimson, AE, Lewsey, J.D., Dawwas, M.F., Gimson, A.E., Lewsey, JD, Copley, L.P., Dawwas, MF   +9 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Palliative care and end stage liver disease: A cohort analysis of palliative care use and factors associated with referral

Annals of Hepatology
Introduction and Objectives: Prevalence and mortality of chronic liver disease have risen significantly. In end stage liver disease, the survival of patients is approximately two years. Despite the poor prognosis and high symptom burden of these patients,
Hugo M Oliveira, Helena Pessegueiro Miranda, Francisca Rego, Rui Nunes   +3 more
doaj   +1 more source

Elaboração de protocolo para cuidados intensivos pós-operatórios em pacientes submetidos a transplante hepático no Hospital Universitário Polydoro Ernani de São Thiago [PDF]

, 2015
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Cuidados Intensivos e Paliativos, Florianópolis, 2015.O transplante hepático surgiu durante a década de 1960, como ...
Lunardelli, Elizabeth Kristiane Buss
core  

Immune-Mediated Liver Disease in the Transplanted Liver

, 2020
Liver transplantation has evolved as the treatment of choice for many patients with end-stage liver disease. Currently, survival posttransplant is excellent, with 10-year survival exceeding 65%.
Sanchez-Fueyo, Alberto, Vionnet, Julien, Neuberger, James   +2 more
core   +1 more source