Results 111 to 120 of about 368,340 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Assessment of health-related quality of life and related factors in patients with chronic liver disease

Brazilian Journal of Infectious Diseases, 2015
Background and objectives: Assessing health-related quality of life is an important aspect of clinical practice. Thus, the present study attempts to assess the health-related quality of life of patients with chronic liver disease.
Neila Paula de Souza, Livia Melo Villar, Artênio José Ísper Garbin, Tânia Adas Saliba Rovida, Cléa Adas Saliba Garbin   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation

, 2000
The prerequisite for liver transplantation as a therapeutic option for inherited metabolic diseases should be that the enzyme defect, being responsible for the major clinical (hepatic and/or extra-hepatic) abnormalities, is localised in the liver ...
Jong, K.P. de, van Spronsen, FJ, de Jong, KP, Peeters, P.M., Reijngoud, D.J., Bijleveld, CMA, Smit, GPA, Reijngoud, DJ; id_orcid, Schweizer, JJ, Spronsen, D.J. van, Visser, G., Smit, G.P., Schweizer, J.J., Slooff, M.J.H., Peeters, PMJG, Slooff, MJH, Niezen-Koning, K.E., Ruitenbeek, W., Rake, JP, Visser, G, Bijleveld, C.M., Ruitenbeek, W, Niezen-Koning, KE; id_orcid, Niezen-Koning, KE, Reijngoud, DJ, Rake, J.P.   +25 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cluster analysis of Model for End-stage Liver Disease and European System for Cardiac Operative Risk Evaluation for predicting operative mortality after concomitant tricuspid valve surgeryCentral MessagePerspective

JTCVS Structural and Endovascular
Objective: Patients requiring concomitant tricuspid surgery represent a heterogeneous cohort with significant comorbidities and varying degrees of organ and right ventricular dysfunction.
Kevin Lim, FRCS (Ed), Antony Chin Ching Au, MB ChB, Matthew Ming Hon Hui, MRCS (Ed), Ivan Chi Hin Siu, MRCS (Ed), Simon Chi Ying Chow, FRCS (Ed), Jacky Yan Kit Ho, FRCS (Ed), Song Wan, FRCS (Ed), FACC, Randolph Hung Leung Wong, FRCS (Ed)   +7 more
doaj   +1 more source

Reinfusion of highly purified CD133+ bone marrow-derived stem/progenitor cells in patients with end-stage liver disease: a phase I clinical trial

, 2015
Background: Bone marrow stem/progenitor cells seem to be effective in liver regeneration after tissueinjury. Aim: To evaluate the feasibility and safety of the mobilization and reinfusion of CD133+stem/progenitorcells in patients with end-stage liver ...
BERNARDI, MAURO, Montemurro, T, Casadei, Andrea, ANDREONE, PIETRO, Viganò, M, Foschi, F, Rizzi, S, Margini, C, Giordano, Rosaria, DAN, ELISA, CATANI, LUCIA, BRODOSI, LUCIA, Viganò, Mariele, Giudice, Valeria, Lorenzini, Stefania, Lemoli, R.M., Montemurro, Tiziana, Giudice, V, Foschi, Francesco G., CONTI, FABIO, LEMOLI, ROBERTO MASSIMO, Lorenzini, S, Rizzi, Simonetta, Giordano, R, NICOLINI, BENEDETTA, Margini, Cristina, SOLLAZZO, DARIA, MALVI, DEBORAH, Casadei, A   +28 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Pharmacotherapy for Nonalcoholic Fatty Liver Disease

, 2015
Lifestyle modifications and optimization of the management of cardiometabolic comorbidities are currently the mainstay of treatment for patients with nonalcoholic fatty liver disease.
Chalasani, Naga, Gawrieh, Samer
core   +1 more source