Results 71 to 80 of about 11,301,269 (256)

Assessment and management of comorbidities (including cardiovascular disease) in patients with nonalcoholic fatty liver disease

, 2012
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. Nonalcoholic steatohepatitis, the progressive form of NAFLD, can lead to end‐stage liver disease and hepatocellular carcinoma.
Vuppalanchi, Raj, Corey, Kathleen E.
core   +1 more source

Clinical applications of the Model for End-Stage Liver Disease (MELD) in hepatic medicine

Hepatic Medicine: Evidence and Research, 2013
Tsang Lau, Jawad AhmadDivision of Liver Diseases, Mount Sinai School of Medicine, New York, USAAbstract: The Model for End-Stage Liver Disease (MELD) score incorporates serum bilirubin, creatinine, and the international normalized ratio (INR) into a ...
Lau T, Ahmad J
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Nature of Malnutrition in Children with End-Stage Liver-Disease Awaiting Orthotopic Liver-Transplantation

, 1992
To evaluate malnutrition in chronic liver disease, and its relationship to nutrient deficiencies and hepatic dysfunction, 27 children with end-stage liver disease were studied. Mean protein-energy intakes were 70% of recommended daily intakes.
TH Ong, RW Shepherd, Lynch, S. V., Shepherd, RW, Thomas, B. J., Patrick, M. K., Wilcox, JA, SV Lynch, Wilcox, J. A., Patrick, MK, Thomas, BJ, Strong, R, Cleghorn, Geoffrey J., Shepherd, R. W., Chin, S. E., Strong, R., R Strong, GJ Cleghorn, JA Wilcox, Cleghorn, GJ, Ong, TH, Chin, SE, Lynch, SV, MK Patrick, BJ Thomas, Ong, T. H., SE Chin   +26 more
core   +1 more source

Model for End-Stage Liver Disease, Model for Liver Transplantation Survival and Donor Risk Index as predictive models of survival after liver transplantation in 1,006 patients

Clinics, 2015
OBJECTIVES: Liver transplantation has not increased with the number of patients requiring this treatment, increasing deaths among those on the waiting list.
Elisa Maria de Camargo Aranzana, Adriana Zuolo Coppini, Maurício Alves Ribeiro, Paulo Celso Bosco Massarollo, Luiz Arnaldo Szutan, Fabio Gonçalves Ferreira   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Keeping high model for end‐stage liver disease score liver transplantation candidates alive

, 2015
As the mean Model for End-Stage Liver Disease (MELD) score at time of liver transplantation continues to increase, it is crucial to implement preemptive strategies to reduce wait-list mortality.
Josh Levitsky, O'Leary, Jacqueline G, Levitsky, Josh, David P. Foley, Orloff, Susan L, Susan L. Orloff, Martin, Paul, Paul Martin, Foley, David P, Jacqueline G. O'Leary   +9 more
core   +1 more source

Implementation of a living donor liver transplantation program in the Republic of Uzbekistan: a report of the first 40 cases

Clinical Transplantation and Research
Background : Living donor liver transplantation (LDLT) is an effective treatment for patients with end-stage liver disease. This study was performed to evaluate the outcomes of the initial series of LDLT procedures performed in the Republic of Uzbekistan
Konstantin Semash, Timur Dzhanbekov, Mirshavkat Akbarov, Miraziz Mirolimov, Azimjon Usmonov, Navruz Razzokov, Ziyodulla Primov, Temurbek Gaybullaev, Sardor Yigitaliev   +8 more
doaj   +1 more source

Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis

Annals of Hepatology, 2018
Introduction. Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in ...
Telma Erotides da Silva, Mariana Costa-Silva, Carina G. Correa, Giovana Denardin, Maria L. Ayres Alencar, Mara S. Pacheco Honório Coelho, Letícia Muraro-Wildner, Maria Luiza-Bazzo, David A. González-Chica, Esther Buzaglo Dantas-Correa, Janaína L. Narciso-Schiavon, Leonardo de Lucca Schiavon   +11 more
doaj   +1 more source