Results 121 to 130 of about 364,848 (300)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Learning to reconstruct: a differentiable approach to muon tracking at the LHC

Machine Learning: Science and Technology
Reconstructing the trajectories of charged particles in high-energy collisions requires high precision to ensure reliable event reconstruction and accurate downstream physics analyses.
Andrea Coccaro, Francesco Armando Di Bello, Lucrezia Rambelli, Stefano Rosati, Carlo Schiavi   +4 more
doaj   +1 more source

Specific Position and Influence of Moisture in Newly-Installed Composite Insulators

CSEE Journal of Power and Energy Systems
Abnormal heating of composite insulators is a hidden threat to safe operation of transmission lines. Although moisture is considered the key factor leading to temperature rise in high humidity areas, specific position and diffusion path of moisture are ...
Sida Zhang, Li Cheng, Ruijin Liao, Yunfan Liu   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fit for an End

Analysis, 2020
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Microconical interface fitting and interface grasping tool

, 1994
A small and light weight microconical interface fitting may be attached to the surface of a space vehicle or equipment to provide an attachment device for an astronaut or robot to capture the space vehicle or equipment. The microconical interface fitting
Johnston, Alistair P., Gernhardt, Michael L., Wightman, William D.   +2 more
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Self-Healing Epoxy to Prevent EAC of Wires within the End Fitting

It has been seen that there is a risk of corrosion or cracking of armour wires within the end fitting in extreme environments / conditions if the epoxy in the end fitting cavity is cracked.
Baker Hughes Company
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Local 598 (Pasco) and Harless, et. al. and Washington State Board of Negotiators - National Labor Relations Board, 1955-1958, Part 2

, 1955
© •* 1 2 3 4 5 .6 8 9 10 11 12 13 14 IS 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 J. r% UNITED STATES OP AMERICA BEFORE THE NATIONAL LABOR RELATIONS BOARD NINETEENTH REGION PLUMBERS AND STBAMFITTERS LOCAL UNION 598 OP THE UNITED ASSOCIATION OP ...
United Association of Journeymen and Apprentices of the Plumbing and Pipe Fitting Industry. Washington State Association
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