Results 101 to 110 of about 7,895,670 (311)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change
BMC Geriatrics, 2018 Background Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings.
J. Gilissen +6 more
doaj +1 more source
Understanding the Cost of End-of-Life Care in Different Settings [PDF]
, 2012 This briefing draws on Marie Curie's experience as the leading organisation in end of life care to consider the economic impact of providing care to patients in the community, rather than in the acute ...
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
End-of-Life Grantmaking in the United States: Summary Report [PDF]
, 2015 The introduction to an in-depth field scan that surveys United States foundation funding around end-of-life issues (especially work involving media and public engagement), this report first reviews the history and context of end-of-life grantmaking in ...
Christine Sherry
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Research, recruitment and observational data collection in care homes: lessons from the PACE study
BMC Research Notes, 2019 Objective Care homes are a common place of death for older adults, especially those with complex health needs or dementia. Representative, internationally comparable data on care home facilities and their residents is needed to monitor health and ...
Danni Collingridge Moore +6 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Suicidal Ideation in Bereavement: A Systematic Review
Behavioral Sciences, 2019 Background: Bereavement is associated with impaired mental health, increases in adverse health behaviors, and heightened risk of suicidal ideation, attempts, and death by suicide.
Nicolette Molina +6 more
doaj +1 more source