Results 111 to 120 of about 177,071,838 (308)

Correction: Palliative care symptoms, concerns and well-being of older people with frailty and complex care needs upon hospital discharge: a cross-sectional study

BMC Palliative Care, 2022
Kim de Nooijer, Nele Van Den Noortgate, Peter Pype, Lieve Van den Block, Lara Pivodic   +4 more
doaj   +1 more source

How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change

BMC Geriatrics, 2018
Background Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings.
J. Gilissen, L. Pivodic, C. Gastmans, R. Vander Stichele, L. Deliens, E. Breuer, L. Van den Block   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Living Memory Home for Dementia Care Pairs (LMH-4-DCP): study protocol for a pilot randomized trial of a web-based reminiscence intervention for family caregivers and persons with dementia

Pilot and Feasibility Studies
Background Family caregivers provide most of the emotional, physical, and logistical support for people living with Alzheimer’s disease and related dementias (ADRD).
Francesca B. Falzarano, Annabelle Greenfield, Sydney C. Saviano, Sindhu Kolla, Sosi Korian, Francesco Osso, Joseph Miller, Paul K. Maciejewski, Heather E. Whitson, Holly G. Prigerson   +9 more
doaj   +1 more source

Conscience at the End of Life

Nursing Reports
This paper reviews the ethical issues involved and argues that each of the usual policies for handling conscientious refusals faces serious challenges. Healthcare providers who refuse to provide medical services should be expected to explain their reasons, make prompt referrals, and bear some of the resulting costs or burdens.
Ralph Neil Baergen, James Skidmore
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The development of a questionnaire to assess the attitudes of older people to end-of-life issues (AEOLI)

, 2005
Objectives: To develop an end-of-life attitudes questionnaire for use in a large community-based sample of older people. Design: Nominal groups and standardization of questions.
Blizard, R., Blanchard, M., King, M., Addington-Hall, J., Catt, S., Zis, M., Catt, Susan, Blizard, Bob, Addington-Hall, Julia, King, Michael, Blanchard, Martin, Zis, Maria   +11 more
core   +1 more source

The central role of housing key workers in supporting healthcare interactions for people experiencing homelessness and implications for palliative care: a qualitative study

BMC Palliative Care
Background People experiencing homelessness access specialist palliative care late in their illness trajectory, if at all. There is also little evidence they receive generalist palliative care or are given opportunities to engage in Advance Care Planning.
Merryn Gott, Lisa Williams, Janine Wiles, Stella Black, Tess Moeke-Maxwell, Jackie Robinson, Te Ārai Palliative Care and End of Life Research Group   +6 more
doaj   +1 more source