Results 131 to 140 of about 177,071,838 (308)

End of Life Law in Australia

, 2016
End of Life Law in Australia provides accurate, practical and relevant information to assist you in navigating the challenging legal issues that can arise with end of life decision-making.\ud \ud This website is an initiative of the Australian Centre for
White, Benjamin P., Willmott, Lindy, Neller, Penny   +2 more
core  

Integrating palliative care into respiratory care for people with advanced COPD: study protocol for the international EU PAL-COPD stepped wedge cluster randomised controlled trial of the ICLEAR-EU intervention

BMJ Open Respiratory Research
Introduction Individuals with advanced chronic obstructive pulmonary disease (COPD) often experience significant symptom burden, unmet care needs and frequent hospitalisations, yet remain underserved by palliative care.
, Catherine Walshe, Luc Deliens, Kim Beernaert, Koen Pardon, Yvonne Engels, Nancy Preston, Peter May, Libby Sallnow, Mogens Grønvold, Julie Stevens, Nanna Maria Hammer, Ágnes Csikós, Paul Marsden, Els Verschuur, Sandra Martins Pereira, Laure Dombrecht, Kim Eecloo, Andre Ribeiro, Frederick Daenen, Michelle Martine Huub Van Der Meer, Anne Wichmann, Diogo Queiroz Almeida, Pablo Hernández-Marrero, Mishka Beutels, Manon Wubbels, Marie Van de Walle, Tim Gatheral, Didar Karadag Akkaya, Elham Nikram, Maria Conceição Silva, Eva Poszgai, Balázs Daniel Fülöp, Réka Gajdócsi   +33 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

End-of-Life Discussion

Voices in Bioethics, 2014
The discussion around end-of-life issues largely centers on the right of the patient to choose (to refuse life sustaining treatment, or, in some cases, to end his or her life through physician assisted suicide or euthanasia where it has been legalized) or to preserve life through invasive treatment.
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The “End of Life” Stage

The Primary Care Companion For CNS Disorders, 2012
One of the more important books that I have read talks about the different segments of one's life.1 The concept of life stage has been useful for treating a variety of people at different times of their lives. When puberty or the calendar ushers in adolescence, a new life stage begins.
openaire   +3 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The needs, preferences, and experiences of LGBT + people living with dementia: a systematic review with thematic synthesis

BMC Geriatrics
Background LGBT + people are disproportionately at an increased risk for developing dementia. Dementia can compound the impact of stigma and social marginalisation experienced by LGBT + people, and is likely to create barriers to accessing healthcare ...
Claude Chidiac, Catherine Walshe, Jane Lowers, Nancy Preston   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source